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Bacterial infections
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Generic Name and Formulations:

Ceftolozane, tazobactam; 1.5g/vial; pwd for IV infusion after reconstitution; preservative-free; contains sodium chloride 487mg/vial.

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Indications for ZERBAXA:

Susceptible complicated intra-abdominal infections in combination with metronidazole and complicated urinary tract infections, including pyelonephritis.


Give by IV infusion over 1 hour. ≥18yrs (CrCl >50mL/min): complicated intra-abdominal infections: usually 1.5g every 8hrs for 4–14 days with IV metronidazole 500mg every 8hrs; complicated urinary tract infections: 1.5g every 8hrs for 7 days. Renal impairment (CrCl 30–50mL/min): 750mg every 8hrs; (CrCl 15–29mL/min): 375mg every 8hrs; ESRD on hemodialysis: 750mg loading dose, followed by 150mg maintenance dose every 8hrs for remainder of treatment (give on dialysis days).


<18yrs: not established.


Cephalosporin, penicillin, or other beta-lactam allergy.


Discontinue if serious hypersensitivity reactions occur. Moderate or severe renal impairment; monitor renal function daily and adjust dose. Elderly. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

Cephalosporin + beta-lactamase inhibitor.

Adverse Reactions:

Nausea, diarrhea, headache, pyrexia, constipation, insomnia, vomiting; C. difficile-associated diarrhea, anaphylaxis.

Generic Availability:


How Supplied:

Single-use vials—10