XIFAXAN 550mg Rx

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XIFAXAN 550mg

Colorectal disorders
Hepatic encephalopathy
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Generic Name and Formulations:

Rifaximin 550mg; tabs.

Select therapeutic use:

Indications for XIFAXAN 550mg:

Irritable bowel syndrome with diarrhea (IBS-D).

Adult:

≥18yrs: 550mg three times daily for 14 days. Recurrent episodes: can retreat up to two times with the same dosage regimen.

Children:

<18yrs: not established.

Warnings/Precautions:

Not studied in patients with MELD scores >25; only 8.6% of patients in the controlled trial had MELD >19. Increased systemic exposure in patients with more severe hepatic dysfunction; caution should be exercised in patients with severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.

Pharmacological Class:

Rifamycin.

Interactions:

Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.

Adverse Reactions:

Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.

How Supplied:

Tabs—60

Indications for XIFAXAN 550mg:

Reduction in risk of overt hepatic encephalopathy recurrence.

Adult:

≥18yrs: 550mg twice daily.

Children:

<18yrs: not established.

Warnings/Precautions:

Not studied in patients with MELD scores >25; only 8.6% of patients in the controlled trial had MELD >19. Increased systemic exposure in patients with more severe hepatic dysfunction; caution should be exercised in patients with severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.

Pharmacological Class:

Rifamycin.

Interactions:

Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.

Adverse Reactions:

Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.

How Supplied:

Tabs—60