Urological Disorders

FDA Approves Nocdurna for Nocturia Due to Nocturnal Polyuria

By June 22, 2018

Nocdurna carries a Boxed Warning for hyponatremia.

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

By June 20, 2018

In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

By June 18, 2018

Researchers conducted a retrospective matched cohort study to compare the risk of death among BPH patients treated with 5ARIs, as monotherapy or in combination with alpha-blockers, and those treated with alpha-blockers alone.

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

By June 12, 2018

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Drug Use Tied to Early Death, Kidney Disease Progression

June 11, 2018

Over the study period, compared with non-smoking throughout follow-up, the multivariable-adjusted hazard ratios were 1.02 (95% confidence interval [CI], 0.86 to 1.21) for CKD progression and 1.86 (95% CI, 1.54 to 2.24) for all-cause mortality for persistent tobacco smoking.

Combo Therapy Appears Effective for Treating Subfertile Men

By June 06, 2018

To evaluate safety and efficacy of this therapy, study authors gathered data on patients treated with the combination from 2014 to 2017.

Positive Results Announced for First-in-Class Metabolic Acidosis Treatment

By June 05, 2018

After 12 weeks, 59.2% of patients treated with the study drug saw an increased blood bicarbonate of ≥4mEq/L or achieved a level in the normal range (22 to 29mEq/L) vs 22.5% of patients in the placebo group (primary endpoint; P <.0001).

AUA: Yoga Can Reduce Urinary Incontinence in Older Women

May 31, 2018

The researchers observed a decrease in total UI frequency by 74 and 51% in the yoga and time-and-attention control groups, respectively.

Raviten Gets Fast Track Status for Intradialytic Hypotension Management

By May 29, 2018

Intradialytic hypotension is a common complication of hemodialysis and can lead to increased morbidity and mortality among patients with end-stage renal disease.

Yonsa Approved for Metastatic Castration-Resistant Prostate Cancer

By May 23, 2018

The approval of Yonsa was based on 2 randomized, placebo-controlled, multicenter Phase 3 studies in patients with mCRPC.

Mecillinam/Pivmecillinam Get QIDP Designation for Complicated UTI

By May 21, 2018

Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.

FDA: PD-L1 Blocking Agents Linked to Decreased Survival in Urothelial Cancer Trials

By May 21, 2018

Data Monitoring Committees (DMC) from two ongoing clinical trials (KEYNOTE-361 and IMVIGOR-130) found that in the monotherapy arms of these studies, patients with low PD-L1 status had decreased survival compared with those who received cisplatin- or carboplatin-based chemotherapy.

AUA: Most Women Report Dysfunctional Toileting Behaviors

May 21, 2018

Overall, 79.9, 64.5, and 97.8% reported premature voiding, straining to void, and delayed voiding, respectively.

AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

By May 18, 2018

"We are confident this guideline is fully aligned with the latest science on treatments for patients with non-metastatic and metastatic CRPC," said Michael Cookson, MD, member of the 2018 amendment panel.

Acute Kidney Injury in Hospital Ups Risk of Later Heart Failure

May 18, 2018

AKI was independently associated with higher rates of the composite outcome of hospitalization for heart failure and atherosclerotic events 1-year post-discharge.

AUA: Guideline on Surgical Management of BPH-Related Lower Urinary Tract Symptoms

By May 17, 2018

The new guideline includes 22 recommendations focused on utilizing common surgical techniques and minimally invasive surgical therapies.

Levitra No Longer Available in Lowest Dosage Strength

By May 16, 2018

The other tablet strengths — 5mg, 10mg, 20mg — will continue to be available in 30-count bottles.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Midstream Urine Microbiome Diverse in Seniors With CKD

May 14, 2018

The remaining samples lacked a dominant genus. High levels of diversity were seen in the samples, as measured by the inverse Simpson, Chao, and Shannon indices.

Postresection intravesical gemcitabine decreases non-muscle-invasive urothelial CA recurrence

May 11, 2018

In this randomized controlled trial, time to recurrence was lower in patient with non-muscle-invasive urothelial cancer when treated with intravesical gemcitabine as compared to saline controls.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C

May 11, 2018

In patients with glomerular filtration rate (GFR) ≥45 mL/min/1.73 m² there was significant improvement in renal biomarkers, as indicated by a progressive increase in mean GFR values until 1 year.

Recent Oral Antibiotics Use Tied to Higher Risk of Nephrolithiasis

May 11, 2018

The strength of these associations was greatest for exposures at younger ages (P<.001) and 3 to 6 months before the index date (P<.001), with all but broad-spectrum penicillins remaining statistically significant 3 to 5 years from exposure.

Gestational Diabetes May Indicate Future Subclinical Renal Issues

May 10, 2018

Women with a history of gestational diabetes had significantly higher estimated glomerular filtration rate, even if they had not subsequently developed diabetes.

Can coaching improve water intake, outcomes in those with chronic disease?

May 09, 2018

In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

By May 03, 2018

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Older Adults Agree Sex Is Important Part of Relationships

May 03, 2018

Forty percent indicated that they were currently sexually active; sexual activity decreased with age. More than half (54%) of respondents agreed that sex is important to their overall quality of life, with men more likely to agree than women (70 versus 40%).

FDA-Approved Treatment for Nocturia Due to Nocturnal Polyuria Launched

By May 01, 2018

Noctiva was approved by the Food and Drug Administration (FDA) in March 2017 based on findings from two 12-week, randomized, double-blind, placebo-controlled trials (N=1045) in patients with nocturia due to nocturnal polyuria.

FDA Approves Myrbetriq Combo Treatment for Overactive Bladder

By April 30, 2018

In clinical trials, the combination of Myrbetriq + solifenacin succinate was associated with greater improvements in the number of incontinence episodes per 24 hours (primary endpoint), the number of micturations per 24 hours (primary endpoint), and the volume voided per micturation (secondary endpoint) compared to placebo or to individual active components.

Anticholinergic Drug Use and Dementia: What's the Link?

By April 26, 2018

A total of 14,453 (35%) cases and 86,403 (30%) controls were prescribed at least 1 anticholingeric drug with an Anticholinergic Cognitive Burden (ACB) score of 3; 1429 (3.5%) cases and 7909 (2.8%) controls were prescribed drugs with an ACB score of 2; most patients (89% of cases and 87% of controls) received a drug with an ACB score of 1 during the drug exposure period (DEP).

Better UTI resolution with 5-day nitrofurantoin over single-dose fosfomycin

April 25, 2018

In this randomized controlled trial, women with uncomplicated urinary tract infections receiving 5-days of nitrofurantoin experienced increased clinical and microbiologic resolution at 28 days compared to single-dose fosfomycin.