Urological Disorders

Hydralazine Linked to Amenorrhea in Premenopausal Patient

By September 18, 2018

This case highlights a possible relationship between the administration of hydralazine and the development of amenorrhea.

Caffeine Consumption Appears to Reduce the Risk of Death in CKD Patients

By September 12, 2018

Using data from the National Health and Nutrition Examination Survey (1999-2010), researchers evaluated caffeine consumption among 4863 non-institutionalized adults with CKD to determine the association between caffeine intake and mortality in these patients.

Efficacy, Safety of PSA Testing for Prostate Cancer Screening Investigated

September 06, 2018

Odds of choosing screening up for men with family history, African descent, low socioeconomic status

CDC: Increase in Rate of STDs for Fourth Consecutive Year in US

September 05, 2018

Nearly 2.3 million total cases of chlamydia, gonorrhea, syphilis diagnosed in the United States in 2017

Nalbuphine Can Relieve Opioid-Induced Urine Retention

September 04, 2018

During the first 6 hours after receiving the drug, the patient voided 850mL, and pain remained controlled. On ultrasonography, bladder volume was 77mL one day later.

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

August 31, 2018

Adjusted rates of revisits leading to admission were similar between patients who received parenteral antibiotics and those who did not receive parenteral antibiotics (risk difference, 0.3%).

Noctiva Spray Shown to Cut Nocturic Voids, Extend Uninterrupted Sleep Time

By August 30, 2018

In 1 analysis of FUSP, which the Company state included ~55% of patients age ≥65, the mean FUSP was extended from 2.4 to 2.5 hours at baseline to ≥4 hours for a group who received 1.66mcg of Noctiva, and ~4 hours for a group who received 0.83mcg of Noctiva.

Bethanechol Prescribing Patterns Examined in Women With Bladder Dysfunction

By August 22, 2018

While bethanechol, a cholinergic agonist, may "theoretically" improve detrusor contractility in women with underactive bladder (UAB), the evidence supporting its use is limited.

AAP Outlines Appropriate Pediatric Nephrology Testing

August 20, 2018

Follow-up urine cultures should be avoided after treatment for an uncomplicated urinary tract infection in patients with evidence of clinical resolution of infection.

Keytruda, Tecentriq Labeling Updated With PD-L1 Testing Requirements

By August 17, 2018

The Dako PD-L1 IHC 22C3 PharmDx Assay has been approved as a companion diagnostic to identify patients with with locally advanced or metastatic urothelial carcinoma who are cisplatin-ineligible for treatment with Keytruda.

Vicinium Fast-Tracked for Non-Muscle Invasive Bladder Cancer

By August 10, 2018

A Phase 3 trial (Vista) of the treatment is currently taking place; the trial is evaluating the treatment in patients with NMIBC who have previously received 2 courses of BCG and who are now BCG-unresponsive.

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

August 07, 2018

"In summary, this trial provides reassuring (albeit preliminary) evidence that kidneys from HCV-infected donors may be safely transplanted into HCV-negative recipients," the authors write.

Tamsulosin Does Not Appear to Promote Urinary Stone Passage

August 01, 2018

The researchers found that stone passage rates were 50% in the tamsulosin group and 47% in the placebo group (relative risk, 1.05; 95.8% confidence interval, 0.87 to 1.27; P=.60).

FDA: Energy-Based Devices Should Not Be Used for Vaginal "Rejuvenation"

By July 31, 2018

The Agency has become aware of some manufacturers marketing these devices for vaginal "rejuvenation" or vaginal cosmetic procedures.

FDA Clears Smartphone-Enabled Urinalysis Kit for Home Use

By July 25, 2018

The Dip.io kit works in tandem with existing smartphone cameras and a dedicated app.

Zemdri Now Available for the Treatment of Complicated UTI, Pyelonephritis

By July 20, 2018

Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

Canagliflozin Trial for T2D With CKD Stopped Early Due to Positive Results

By July 17, 2018

A clinical trial assessing canagliflozin (Invokana; Janssen) as an addition to standard-of-care in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) has been stopped early after meeting its pre-specified efficacy criteria.

FDA Approves Expanded Prostate Cancer Indication for Xtandi

By July 16, 2018

The approval was based on data from the Phase 3 PROSPER trial which enrolled 1401 patients with non-metastatic CRPC.

Does Metformin Use Increase the Risk of Acidosis in CKD?

July 12, 2018

Time-dependent metformin use was not associated with incident acidosis overall or in those with eGFR 45 to 59 and 30 to 44 mL/min/1.73 m² (aHR, 1.16 [95% CI, 0.95 to 1.41] and 1.09 [95% CI, 0.83 to 1.44]) compared with alternative diabetes management.

Higher Visceral Fat Ratio Seen With Recurring Urolithiasis

July 09, 2018

However, there was no significant difference in visceral fat area (P=.32), subcutaneous fat area (P=.36), visceral fat volume (P=.38), or subcutaneous fat volume (P=.23).

FDA Permits Marketing of Devices to Create Arteriovenous Fistula

July 05, 2018

Two devices designed to create arteriovenous fistula in patients with CKD in need of hemodialysis

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

July 02, 2018

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass

Idaho Pharmacists Able to Prescribe Meds for Several Conditions on July 1

By June 27, 2018

The new rule allows pharmacists to prescribe medications for cold sores, seasonal influenza, strep throat, and urinary tract infections, as well as statins for patients with diabetes.

Zemdri Approved to Treat Complicated Urinary Tract Infections

By June 26, 2018

Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

FDA Approves Nocdurna for Nocturia Due to Nocturnal Polyuria

By June 22, 2018

Nocdurna carries a Boxed Warning for hyponatremia.

Dulaglutide Assessed in T2D Patients With Chronic Kidney Disease

By June 20, 2018

In AWARD-7, eligible patients (N=577) were randomized to receive dulaglutide 1.5mg once-weekly (N=193), dulaglutide 0.75mg (N=190) once-weekly, or insulin glargine daily (N=194), all in combination with insulin lispro, for 52 weeks. HbA1c at 26 weeks with a 0.4% non-inferiority margin was designated as the primary outcome, while secondary outcomes included eGFR and urine albumin-to-creatinine ratio.

Mortality Risk Compared Among Men Receiving Drug Therapy for BPH/LUTS

By June 18, 2018

Researchers conducted a retrospective matched cohort study to compare the risk of death among BPH patients treated with 5ARIs, as monotherapy or in combination with alpha-blockers, and those treated with alpha-blockers alone.

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

By June 12, 2018

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Drug Use Tied to Early Death, Kidney Disease Progression

June 11, 2018

Over the study period, compared with non-smoking throughout follow-up, the multivariable-adjusted hazard ratios were 1.02 (95% confidence interval [CI], 0.86 to 1.21) for CKD progression and 1.86 (95% CI, 1.54 to 2.24) for all-cause mortality for persistent tobacco smoking.

Combo Therapy Appears Effective for Treating Subfertile Men

By June 06, 2018

To evaluate safety and efficacy of this therapy, study authors gathered data on patients treated with the combination from 2014 to 2017.