Urologic Disorders

SGLT2 Inhibitors and Urinary Tract Infections: What's the Link?

By December 17, 2018

For this study, the authors identified randomized controlled trials (RCTs) that compared SGLT2 inhibitors with placebo, no treatment, or another antidiabetic agent and reported on UTI outcome.

Risk Factors for Overactive Bladder and Urinary Incontinence

December 11, 2018

Risk factors for overactive bladder and urinary incontinence chart in men and women.

Chronic Kidney Disease Burden Increasing in the US

December 07, 2018

The researchers found that during the study period, CKD disability-adjusted life years increased by 52.6%. Death due to CKD increased by 58.3%, from 52,127 to 82,539 deaths.

Overactive Bladder Treatment: Which Is the Most Cost-Effective Option?

By December 06, 2018

Study authors developed a Markov model with health states based on daily urinary incontinence episodes (UIEs) to compare the cost-effectiveness of onabotulinumtoxinA, implantable sacral nerve stimulation devices, percutaneous tibial nerve stimulation, anticholinergic medications, and mirabegron versus BSC for the management of refractory OAB.

Exposure to Phthalates May Impact Timing of Puberty

December 05, 2018

Exposure to certain endocrine-disrupting chemicals may impact the timing of puberty in children.

Nocdurna Now Available for Nocturia Due to Nocturnal Polyuria

By November 09, 2018

The antidiuretic effects of desmopressin are mediated by stimulation of vasopressin 2 (V2) receptors, thereby increasing water reabsorption in the kidneys, and reducing urine production.

Zoliflodacin found to effectively treats urogenital gonorrhea

November 08, 2018

Patients with uncomplicated urogenital gonorrhea treated with the novel antibiotic zoliflodacin, developed in part due to increasingly antibiotic resistant gonorrhea, were cured at rates similar to that seen in patients treated with ceftriaxone.

Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI

November 07, 2018

Exposed patients with ESC-R EB UTIs were matched to unexposed patients with EB UTIs based on study year (151 in each group).

Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

November 02, 2018

"We believe that the data actually suggest possible benefit for ESKD [end-stage kidney disease] with intensive glucose control, and remain inconclusive for intensive blood pressure control and fibrate use given the wide confidence intervals for the more reliable ESKD outcomes," write the authors.

Contepo NDA Submitted for Treatment of Complicated UTI

By November 01, 2018

Contepo, an investigational epoxide intravenous (IV) antibiotic, has broad spectrum activity against Gram-negative and Gram-positive pathogens, including multi-drug resistant strains such as ESBL-producing Enterobacteriaceae.

High-Dose, Proactive IV Iron Noninferior in Hemodialysis

November 01, 2018

The researchers found that patients received a median monthly iron dose of 264 and 145mg in the high- and low-dose groups, respectively.

Mitomycin Gel Granted Breakthrough Tx Designation for Urothelial Cancer

By October 31, 2018

UGN-1 is an investigational formulation of mitomycin, delivered to patients using standard intravesical catheters.

Oral Urinary Tract Infection Treatments

October 29, 2018

Oral antibiotics for urinary tract infections (UTIs) treatment chart including dosing and duration.

Overactive Bladder & Urinary Incontinence Treatments

October 29, 2018

Overactive bladder and urinary incontinence dosing regimen chart for anticholinergics, antispasmodic/anticholinergics, muscarinic antagonists, and synthetic vasopressin.

Cefiderocol Compared to Imipenem-Cilastin in Complicated UTI

October 29, 2018

A total of 252 patients in the cefiderocol group and 119 patients in the imipenem-cilastatin group had a qualifying Gram-negative uropathogen and were included in the analysis of the primary end point of a composite of clinical and microbiological outcomes seven days after cessation of treatment.

High-Dose Flu Vaccine May Cut Hospitalization in Dialysis Patients

October 24, 2018

The researchers found that by vaccine type, the adjusted rates of first hospitalization were 8.43, 7.88, and 7.99 per 100 patient-months, respectively, and rates for death were 1.00, 0.97, and 1.04, respectively; these differences were not significant.

Early, delayed renal-replacement examined in septic shock associated acute kidney injury

October 19, 2018

Among patients with septic shock and acute kidney injury, there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT).

Posttransplant Outcomes Assessed in Patients Who Resumed TNFi Therapy

By October 18, 2018

Of the 5256 patients who received a renal transplant in the study window (1/1/1998 - 12/31/2017), 14 met inclusion criteria.

Effect of Renal-Replacement Timing Examined in Kidney Injury, Sepsis

October 11, 2018

After the second planned interim analysis, the trial was stopped early for futility. The researchers found that 58% of patients in the early-strategy group and 54% in the delayed-strategy group had died (P= 0.38).

Increasing Water Intake Can Cut Cystitis Recurrence

October 03, 2018

There were 327 cystitis episodes overall, 111 and 216 in the water and control groups, respectively.

Patients Report Poorer Dialysis Service in Certain Settings

September 24, 2018

Larger proportions of the overall between-facility variation in ICH-CAHPS scores were explained by geographic location and dialysis facility characteristics than patient characteristics.

Hydralazine Linked to Amenorrhea in Premenopausal Patient

By September 18, 2018

This case highlights a possible relationship between the administration of hydralazine and the development of amenorrhea.

Caffeine Consumption Appears to Reduce the Risk of Death in CKD Patients

By September 12, 2018

Using data from the National Health and Nutrition Examination Survey (1999-2010), researchers evaluated caffeine consumption among 4863 non-institutionalized adults with CKD to determine the association between caffeine intake and mortality in these patients.

Lower patient satisfaction reported at for-profit dialysis centers

September 11, 2018

Patient reported experience has recently been incorporated into Quality Incentive Programs for dialysis centers across the United States. Lower patient experience scores were reported in for-profit, free-standing, and large dialysis organization centers.

Efficacy, Safety of PSA Testing for Prostate Cancer Screening Investigated

September 06, 2018

Odds of choosing screening up for men with family history, African descent, low socioeconomic status

CDC: Increase in Rate of STDs for Fourth Consecutive Year in US

September 05, 2018

Nearly 2.3 million total cases of chlamydia, gonorrhea, syphilis diagnosed in the United States in 2017

Nalbuphine Can Relieve Opioid-Induced Urine Retention

September 04, 2018

During the first 6 hours after receiving the drug, the patient voided 850mL, and pain remained controlled. On ultrasonography, bladder volume was 77mL one day later.

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

August 31, 2018

Adjusted rates of revisits leading to admission were similar between patients who received parenteral antibiotics and those who did not receive parenteral antibiotics (risk difference, 0.3%).

Noctiva Spray Shown to Cut Nocturic Voids, Extend Uninterrupted Sleep Time

By August 30, 2018

In 1 analysis of FUSP, which the Company state included ~55% of patients age ≥65, the mean FUSP was extended from 2.4 to 2.5 hours at baseline to ≥4 hours for a group who received 1.66mcg of Noctiva, and ~4 hours for a group who received 0.83mcg of Noctiva.

Bethanechol Prescribing Patterns Examined in Women With Bladder Dysfunction

By August 22, 2018

While bethanechol, a cholinergic agonist, may "theoretically" improve detrusor contractility in women with underactive bladder (UAB), the evidence supporting its use is limited.