Urinary Tract Discomfort

Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI

November 07, 2018

Exposed patients with ESC-R EB UTIs were matched to unexposed patients with EB UTIs based on study year (151 in each group).

Cefiderocol Compared to Imipenem-Cilastin in Complicated UTI

October 29, 2018

A total of 252 patients in the cefiderocol group and 119 patients in the imipenem-cilastatin group had a qualifying Gram-negative uropathogen and were included in the analysis of the primary end point of a composite of clinical and microbiological outcomes seven days after cessation of treatment.

Increasing Water Intake Can Cut Cystitis Recurrence

October 03, 2018

There were 327 cystitis episodes overall, 111 and 216 in the water and control groups, respectively.

Nalbuphine Can Relieve Opioid-Induced Urine Retention

September 04, 2018

During the first 6 hours after receiving the drug, the patient voided 850mL, and pain remained controlled. On ultrasonography, bladder volume was 77mL one day later.

Pediatric Revisits, Admissions for UTI Similar With Oral or IV Meds

August 31, 2018

Adjusted rates of revisits leading to admission were similar between patients who received parenteral antibiotics and those who did not receive parenteral antibiotics (risk difference, 0.3%).

AAP Outlines Appropriate Pediatric Nephrology Testing

August 20, 2018

Follow-up urine cultures should be avoided after treatment for an uncomplicated urinary tract infection in patients with evidence of clinical resolution of infection.

Zemdri Now Available for the Treatment of Complicated UTI, Pyelonephritis

By July 20, 2018

Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

Idaho Pharmacists Able to Prescribe Meds for Several Conditions on July 1

By June 27, 2018

The new rule allows pharmacists to prescribe medications for cold sores, seasonal influenza, strep throat, and urinary tract infections, as well as statins for patients with diabetes.

Zemdri Approved to Treat Complicated Urinary Tract Infections

By June 26, 2018

Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

AUA: Yoga Can Reduce Urinary Incontinence in Older Women

May 31, 2018

The researchers observed a decrease in total UI frequency by 74 and 51% in the yoga and time-and-attention control groups, respectively.

Mecillinam/Pivmecillinam Get QIDP Designation for Complicated UTI

By May 21, 2018

Mecillinam is a beta-lactam antibiotic with a novel site of action which is specific and highly active against Gram-negative bacteria.

FDA Panel Votes on Plazomicin for Complicated UTI, Bloodstream Infections

By May 03, 2018

The Committee voted unanimously (15-0) that substantial evidence on the safety and efficacy of plazomicin was presented for the treatment of cUTI but voted against its use (4-11) for the treatment of bloodstream infections in patients with limited or no treatment options.

Better UTI resolution with 5-day nitrofurantoin over single-dose fosfomycin

April 25, 2018

In this randomized controlled trial, women with uncomplicated urinary tract infections receiving 5-days of nitrofurantoin experienced increased clinical and microbiologic resolution at 28 days compared to single-dose fosfomycin.

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

April 25, 2018

Overall, 74 and 63%, respectively, had microbiologic resolution (difference, 11%). There were few adverse events and they were mainly gastrointestinal, most commonly nausea and diarrhea.

UTI Calculator Predicts Risk of Infant Urinary Tract Infection

April 17, 2018

The researchers analyzed electronic medical records from a training database of 1,686 febrile children (aged 2 to 23 months) presenting to the emergency department.

Inactivity, Prolonged Sitting Tied to Urinary Tract Infections in Men

March 27, 2018

The researchers found that the incidence rate of significant LUTS was 39 per 1,000 person-years. Both low physical activity level and prolonged sitting time were independently associated with the incidence of LUTS after adjustment for multiple factors.

Combination Antibiotics Compared in the Treatment of Complicated UTI

By February 28, 2018

The results showed that meropenem/vaborbactam was non-inferior to piperacillin/tazobactam with an overall success rate of 98.4% vs 94.0%.

Confusion Common in Seniors Prescribed Antibiotics for UTI

January 22, 2018

One in 5 NH residents had received antibiotics within the last 30 days, of which 45% were for UTI.

Sensitivity, Specificity of Urinalysis for UTIs Assessed in Febrile Infants

January 22, 2018

In all groups, specificity was 0.91 (95% CI, 0.90 to 0.91). The sensitivity and specificity of urinalysis was 0.87 (95% CI, 0.83 to 0.90) and 0.91 (95% CI, 0.90 to 0.92), respectively, for UTIs with colony counts ≥10,000 CFUs/mL.

Nitrofurantoin, TMP-SMX Often Prescribed in Early Pregnancy for UTI

By January 17, 2018

A 2011 committee opinion from the American College of Obstetricians and Gynecologists (ACOG) recommended that sulfonamides and nitrofurantoin may be prescribed in the first trimester of pregnancy only when other antimicrobial therapies are deemed clinically inappropriate.

FDA Clears UriVarx Test Strips for UTI Detection

By January 11, 2018

The supplements are intended to reduce urinary urgency, accidents, and day/night frequency in patients with overactive bladder and urinary infections.

NSAID Compared to Antibiotic for Symptomatic Treatment of UTI

By November 09, 2017

The primary endpoint of symptom resolution at day 3 was met by 54% (72/133) in the diclofenac group vs. 80% (96/120) in the norfloxacin group (risk difference 27%, 95% CI 15% to 38%, P=0.98 for non-inferiority, P<0.001 for superiority).

FDA Approves Unique Antibiotic Combo Drug Vabomere

By August 30, 2017

Vabomere is a combination antibiotic that includes meropenem, a penem antibacterial, and vaborbactam, a non-suicidal beta-lactamase inhibitor.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

"UTI" Diagnosis May Lead to Harmful Antibiotic Overtreatment

By June 05, 2017

In their paper, the authors noted that "healthy urinary tracts host a ubiquitous, complex microbial community" and that the presence of these microorganisms are often beneficial to overall well-being.

AUA 'Choosing Wisely' List IDs Unnecessary Tests, Treatments

By May 15, 2017

The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.

Positive Results for Plazomicin for cUTI, CRE Infections

By December 12, 2016

Achaogen has announced positive results from the Phase 3 trials ('EPIC' and 'CARE') of plazomicin, a lead candidate for potential treatment of complicated urinary tract infections (cUTI) and acute pyelonephritis (AP).

Guidelines for UTI in Febrile Infants and Young Children Reaffirmed

November 29, 2016

2011 CPG on urinary tract infection in infants and young children reaffirmed after review of literature

UTI Treatment Leads to Fatal Drug Interaction in a Schizophrenia Patient

By November 23, 2016

This case is the first to describe a fatal outcome with such an interaction.

Year Long Study Examines Efficacy of Cranberry Capsules in Preventing UTIs

October 28, 2016

There is no significant difference in the presence of bacteriuria plus pyuria over one year among older women living in nursing homes receiving cranberry capsules versus a placebo pill, according to a study published online October 27 in the Journal of the American Medical Association. The research was published to coincide with the annual meeting of the Infectious Diseases Society of America (IDWeek), held from Oct. 26 to 30 in New Orleans.