The FDA is requiring updated drug labels and medication guides for fluoroquinolone antibiotics explaining the possibility of permanent peripheral neuropathy. The nerve damage may occur soon after these drugs are taken by mouth or by injection, and may be permanent.
The affected fluoroquinolone drugs include: Levaquin (levofloxacin; Janssen), Cipro (ciprofloxacin; Bayer), Avelox (moxifloxacin; Bayer), Noroxin (norfloxacin; Merck), Factive (gemifloxacin; Cornerstone), and Ofloxacin.
Topical formulations indicated for the ears or eyes are not known to be associated with this risk.
The FDA recommends discontinuing the fluoroquinolone if the patient develops symptoms of peripheral neuropathy. The patient should be switched to another, non-fluoroquinolone antibiotic unless the benefit outweighs the risk. Symptoms include pain, burning, tingling, numbness, weakness, or a change in sensation to light touch, pain or temperature, or the sense of body position.
For more information call (888) 463-6332 or visit FDA.gov.