Prescriber Certification in the Clozapine REMS Program

Starting October 12, 2015, health care professionals who wish to prescribe clozapine to outpatients or inpatients must be certified in the Clozapine REMS Program. To become certified in the Clozapine REMS Program, prescribers must:

  • Review the prescribing information for clozapine,
  • Review Clozapine and the Risk of Neutropenia: A Guide for Healthcare Providers,
  • Successfully pass the Knowledge Assessment for Healthcare Providers, and
  • Complete and submit the one-time Clozapine REMS Prescriber Enrollment Form.
  • Prescribers can be certified through the Clozapine REMS Program website at, or by faxing completed forms to (844) 404-8876. For more information or to request materials, call the Clozapine REMS Program at (844) 267-8678.
  • Prescribers who currently treat patients with clozapine will have additional time to complete their certification and will have access to the Clozapine REMS Program to manage current patients. The Clozapine REMS Program will contact current prescribers to provide instructions on how to access the Clozapine REMS Program website.

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