Twynsta is indicated for the treatment of hypertension as monotherapy or with other antihypertensives or as initial therapy in patients likely to need multiple drugs to achieve blood pressure goals. It combines telmisartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker (CCB).
Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells.
The Company stated the discontinuation was a business decision and that the other tablet strengths are still available: 40mg/5mg, 40mg/10mg, and 80mg/5mg.
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