Trial Tracker

Can liraglutide reduce risk for major cardiac events in elderly diabetics?

December 05, 2018

Type 2 diabetes mellitus continues to increase in prevalence among older adults, with significant associated morbidity and mortality. The authors of this study examined the cardiovascular effects of liraglutide compared to placebo in older patients.

PPI co-therapy reduces gastrointestinal bleeding risk of oral anticoagulants

December 05, 2018

In this retrospective cohort study, rivaroxaban had the highest and apixaban had the lowest upper gastrointestinal bleeding risk.

Fractional-dose vaccination offers long lasting protection against yellow fever

November 30, 2018

Prophylaxis is the mainstay of treatment and prevention for yellow fever, as there is not currently a cure beyond supportive care for those who contract the disease.

ACP releases principles to guide patient partnership in health care

November 28, 2018

Researchers generated 4 principles to identify the role of patients and families in developing physicians' care plans through a multistakeholder advisory committee.

Physical activity in patients with heart failure and cardiovascular outcomes

November 27, 2018

The current analysis of the HF-ACTION trial sought to evaluate the baseline physical activity effect on the responses to exercise training and clinical outcomes.

Parents of children with autism report greater difficulty accessing health care

November 26, 2018

Parents of children with ASD reported higher demands for health care (i.e. were more likely to have seen a medical provider in the past year and have a personal doctor or nurse), but greater difficulty accessing services.

Abdominal hysterectomy vs. minimally invasive technique: Survival in cervical CA

November 25, 2018

To date, long term outcomes of minimally invasive surgery versus open surgery have mainly been studied in retrospective fashion and as a result there is limited data on prospective survival outcomes.

Survival with open surgery vs. minimally invasive radical hysterectomy

November 24, 2018

In this analysis, the authors sought to determine the comparative survival outcomes of minimally invasive radical hysterectomy versus open radical hysterectomy using two weighted national cancer databases.

Peanut allergy effectively treated with oral immunotherapy

November 23, 2018

A new orally available immunotherapy consisting of peanut protein, AR101, may provide a clinically useful method for treating patients with peanut allergy

Omalizumab could be a new rescue option for asthma

November 22, 2018

In a case-report, 41-year-old patient requiring intubation for respiratory failure due to status asthmaticus clinically improved after administration of omalizumab.

Can Nurse Practitioners and Physician Assistants effectively manage chronic conditions?

November 21, 2018

The authors of this study aimed to examine all three PCPs to assess whether NPs and PAs could be a possible solution to workforce shortages.

Diabetes patients with high-deductible care plans may delay seeking crucial care

November 20, 2018

Many Americans have "high-deductible" health insurance policies, which involves plans that require them to pay up to $7000 out-of-pocket annually if they utilize health care services.

Maximum BMI over 24-year weight history linked to increased all-cause mortality

November 20, 2018

Using data from the original and offspring Framingham cohort studies, a 24-year weight history was obtained prior to analysis of mortality.

Marijuana exposure common in children of tobacco smokers

November 19, 2018

While previous studies have suggested that in-utero and early childhood exposure to marijuana smoke may have long-term health consequences, less is known about the prevalence of such exposure.

Recommendations to improve understanding of pediatric global health issues

November 19, 2018

Recommendations encourage improved trainings for pediatricians and trainees on a broad list of socioeconomic and cultural topics affecting pediatric health.

Rates of neurodevelopmental impairment unchanged in infants born ≤500g in Japan

November 16, 2018

Accurate data on long-term neurodevelopmental outcomes is critical for families and physicians to make informed decisions regarding resuscitation and care of these infants.

Concussion or mild traumatic brain injury linked with increased risk of suicide

November 14, 2018

In this large systematic review and meta-analysis, the risk of suicide was 2 times higher for patients with history of at least 1 concussion or mild TBI.

Exercise intervention and functional decline among elderly admitted to hospital

November 14, 2018

There were no adverse outcomes among those patients who underwent the exercise-based intervention.

Cancer may become leading cause of death in the US for high income people

November 13, 2018

The authors observed that lower-income counties were more likely to have heart disease as the leading cause of death.

Risk stratification shows high sensitivity for invasive bacterial infections in febrile infants

November 13, 2018

Authors of this study aimed to evaluate the precision of the Rochester and modified Philadelphia criteria in risk stratifying infants ≤60 days of age with invasive bacterial infection who were seen in the emergency department.

The US leads developed nations in premature deaths from drug overdose

November 13, 2018

The authors observed declining premature drug-overdose mortality rates among men and women in Norway, in addition to men in Spain and women in Denmark.

Sensitive cardiac injury marker could reduce stress testing for myocardial ischemia

November 12, 2018

Routine surveillance stress testing is often costly and overused. Furthermore, current guidelines recommend against routine stress testing in patients with stable ischemic CAD, unless the purpose of the test is to assess new or progressive symptoms.

Inhaled inorganic nitrites do not improve exercise capacity in HFpEF

November 09, 2018

Past studies have suggested the possible utility of organic nitrates/inorganic nitrites in treating Heart Failure with preserved Ejection Fraction.

Zoliflodacin found to effectively treats urogenital gonorrhea

November 08, 2018

Patients with uncomplicated urogenital gonorrhea treated with the novel antibiotic zoliflodacin, developed in part due to increasingly antibiotic resistant gonorrhea, were cured at rates similar to that seen in patients treated with ceftriaxone.

Organic food consumption linked to reduced cancer risk

November 07, 2018

This study is a prospective cohort that evaluated self-reported organic food consumption and incidence of cancer, while adjusting for known cancer risk factors.

E-cigarette users have greater odds of subsequent cigarette use

November 05, 2018

Compared to students who did not use e-cigarettes, a greater proportion of students who used e-cigarettes at baseline had initiated cigarette use on follow-up, and these students had approximately 4-fold higher odds for initiation of cigarette use.

Outcomes of hypertension treatment in low-risk patients

November 05, 2018

The benefit of treating low-risk patients with mild (sustained blood pressure of 140/90-159/99mmHg) hypertension is not clear as these patients are not frequently included in trials given the low incidence rate of major cardiovascular events.

Sildenafil does not improve QoL for idiopathic pulmonary fibrosis patients treated with nintedanib

November 02, 2018

In patients with idiopathic pulmonary fibrosis (IPF) and a low diffusion capacity for carbon dioxide (DLCO), the addition of sildenafil to a treatment regimen of nintedanib did not improve quality of life scores after 12 weeks compared to treatment with nintedanib and a placebo.

Gastric bypass most effective for weight loss among common bariatric procedures

October 31, 2018

Roux-en-Y gastric bypass was found to be the most effective bariatric procedure reviewed in this study in terms of patient weight loss.

ACP updates policy recommendations for reducing gun-related injuries, deaths

October 30, 2018

The American College of Physicians (ACP) revises and expands on current policy recommendations regarding gun-related injuries and deaths.