Trial Tracker

Medications with depression as a possible adverse effect associated with increased risk

June 15, 2018

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

Lower and higher oxygen saturation targets result in equal but contrasting outcomes for preemies

June 14, 2018

In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major disability at a corrected age of 18-24 months for infants born extremely preterm.

Isolated mild/moderate thrombocytopenia may not require intervention

June 11, 2018

In a review of children who presented to a specialist hematology clinic with isolated mild or moderate low platelet counts, though causes were variable, most required no interventions.

Recombinant human pentraxin 2 slows the decline in lung function in idiopathic pulmonary fibrosis

June 07, 2018

The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis.

Survey-based intervention linked to improved communication and goals-of-care discussions

June 06, 2018

Goals-of-care (GOC) discussions were linked to improved patient outcomes and reduction of intensity in end-of-life care. The current study demonstrated that a survey-based intervention for priming clinicians with communication strategies was linked to increase in the occurrence, documentation, and quality of GOC discussions.

Improved calculations suggest major changes to statin, aspirin, and blood pressure Tx

June 06, 2018

Updated risk calculations suggest that fewer people should be classified within the high-risk category for CVD.

Restrictive state alcohol policies may reduce alcohol-related crash fatalities

June 05, 2018

Increasingly restrictive state alcohol policies were associated with reduced odds that a crash fatality was alcohol related, both when blood alcohol levels were above and below the legal limit for driving in the USA (0.08%).

Early endovenous ablation of leg ulcers improves healing

June 05, 2018

Patients with leg ulcers caused by superficial venous reflux treated with compression therapy experienced earlier time to healing if they were treated with early-ablation therapy and opposed to deferred-ablation.

Viruses not linked to asthma exacerbation severity

June 04, 2018

Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure. Evidence Rating Level: 2 (Good).

Radial-artery grafts outperform saphenous-vein grafts when used in CABG

June 04, 2018

Patients undergoing coronary artery bypass grafting (CABG) who received a radial-artery graft rather than a saphenous-vein graft (both groups also received an internal-thoracic-artery graft) experienced fewer major adverse cardiac events at a mean follow-up of 60 months.

Surveillance of DTaP Vaccines Reveals No New Safety Concerns

June 04, 2018

Surveillance of adverse events after diphtheria-tetanus-acellular pertussis (DTaP) vaccine administration reported to the Vaccine Adverse Event Reporting System (VAERS) between 1991 and 2016 revealed no new or unexpected adverse events.

ECMO for severe ARDS does not improve mortality

May 31, 2018

Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) did not show a 60-day mortality benefit compared to conventional ventilation and ECMO rescue therapy.

MRI pattern selects patients with unknown stroke time who benefit from thrombolysis

May 31, 2018

Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized to alteplase were more likely to have a favorable outcome at 90 days than those receiving placebo.

Physicians should look for misuse patterns that lead to overdose before prescribing opioids

May 29, 2018

All opioid misuse patterns examined had a positive association with opioid overdose and death.

Adolescent mothers in protective care more likely to have their children placed in care

May 29, 2018

Children born to adolescent mothers in the care of child protection services (CPS) were more likely to be taken into CPS care themselves when compared to other children in the first 2 years of life.

Safety confirmation of propranolol use in treatment of infantile hemangiomas

May 29, 2018

In healthy infants, there was no significantly increased risk for cardiovascular or metabolic events associated with propranolol use for treatment of infantile hemangioma.

Physicians report feeling moral distress over policies that force inadequate care based on immigration status

May 29, 2018

Physicians working in settings that provide emergency only hemodialysis (EOHD) reported higher rates of professional burnout.

Amyloid-beta (1-40) is a strong predictor of mortality in acute coronary syndrome

May 23, 2018

Patients with the highest Aβ40 also had the worst non-ST-segment elevation acute coronary syndrome (NSTE-ACS) risk profile.

AAP recommends life support training for general public

May 23, 2018

The Committee on Pediatric Emergency Medicine of the American Academy of Pediatrics (AAP) has published a statement in support of bystander CPR and AED training based on a review of their benefits in the public health literature.

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Long-acting buprenorphine depots may be efficacious for opioid use disorder

May 22, 2018

In this double-blind randomized controlled trial, weekly or monthly buprenorphine depot injections were non-inferior to daily sublingual buprenorphine/naloxone in maintaining no evidence of illicit opioid use at 24 weeks in outpatients with opioid use disorder (OUD).

Fremanezumab effective in preventing episodic migraine

May 17, 2018

In this randomized controlled trial, Fremanezumab slightly decreased the amount of headache free days in those with episodic migraines compared to placebo.

Acupuncture does not improve the rate of live births among in vitro fertilization

May 16, 2018

In this randomized controlled trial, administration of acupuncture at the time of ovarian stimulation and embryo transfer did not improve the rate of live births.

Children's hospital visits for suicide ideation and attempts are increasing

May 16, 2018

The percentage of patients seen at children's hospital for suicidal ideation (SI) and suicide attempts (SA) more than doubled between 2008 and 2015.

Surgical repair improves survival, pain control in patients with dementia who suffer hip fracture

May 15, 2018

In this retrospective study, nursing home patients with dementia who had a hip fracture had improved survival if they underwent surgical repair compared to non-surgical management.

Parental cannabis use increasing, cigarette use decreasing

May 14, 2018

Current cannabis use among parents with children at home increased from 4.9% to 6.8% while current cigarette use declined from 27.6% to 20.2% from 2002-2015, as measured by the National Survey on Drug Use and Health.

Postresection intravesical gemcitabine decreases non-muscle-invasive urothelial CA recurrence

May 11, 2018

In this randomized controlled trial, time to recurrence was lower in patient with non-muscle-invasive urothelial cancer when treated with intravesical gemcitabine as compared to saline controls.

Emotional regulation intervention linked to decreased high risk sexual behavior

May 10, 2018

Adolescents with no baseline sexual activity who underwent an emotional regulation sexual health intervention were less likely to report first-time vaginal or anal sex over a follow-up period of 30 months vs adolescents who underwent traditional health promotion without emotional regulation teaching.

Vasopressin plus catecholamines lowers risk of atrial fibrillation in distributive shock

May 09, 2018

In this meta-analysis, addition of vasopressin to catecholamine vasopressors was associated with a lower risk of atrial fibrillation when compared to catecholamine monotherapy.

Can coaching improve water intake, outcomes in those with chronic disease?

May 09, 2018

In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease.