Early intrauterine Zika infection linked to birth defects among infants in the US French Territories
A prospective cohort including pregnant women in the US French Territories with PCR-confirmed Zika virus (ZIKV) infection found a 7% overall risk of neurologic and ocular defects among subsequent offspring.
Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells.
Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B.
Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is common in patients undergoing a right heart catheterization.
Use of ticagrelor resulted in similar rates of major bleeding compared to clopidogrel in patients with ST elevation myocardial infarction treated with thrombolysis.
Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014.
Colonoscopy in veterans was associated with reduced mortality from both left and right-sided colorectal cancer.
Infantile immunization rates were higher among children whose caregivers received compliance-linked incentives when compared to those who received only mobile phone reminders and those who received no intervention.
Intensive blood pressure control not linked to changes in cerebral perfusion in cerebral small vessel disease
In patients with severe cerebral small vessel disease, a strategy of intensive blood pressure control did not significantly alter whole brain blood flow when compared to standard blood pressure control.
Hepatitis B e-antigen (HBe-Ag) positive mothers receiving tenofovir daily from 28-weeks gestation to 2 months postpartum did not show significant reductions in HBV transmission rates compared to placebo treated participants.
Strong state firearm laws were associated with lower firearm suicide and homicide rates and overall suicide rates regardless of surrounding state laws.
Digital health intervention resulted in significantly higher colon cancer screening rates among participants.
In children age 5 to 11 with mild-to-moderate persistent asthma treated with daily inhaled glucocorticoids, quintupling the dose of inhaled glucocorticoids during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
In this pragmatic, randomized controlled trial, opioids did not result in better pain management or function compared to non-opioid treatments for patients with chronic pain.
In this randomized controlled trial, men who were screened with a single PSA test had higher diagnoses of prostate cancer than those who were unscreened.
Female sexual minorities, such as those identifying as lesbian or bisexual, were at increased risk of experiencing teen pregnancy when compared to their heterosexual peers.
Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients.
The American Academy of Pediatrics (AAP) provided a policy statement outlining recommendations to reduce pediatric medication dispensation errors and adverse drug events in emergency rooms.
In this systematic review and meta-analysis, patients with infective endocardititis with vegetations greater than 10mm in size had significantly increased risk of systemic embolism and mortality.
Among patients admitted to the hospital for a provisional diagnosis of cellulitis, early dermatologic consultation was associated with improved recognition of pseudo-cellulitis, decreased antibiotic use, and earlier discharge.
Differences in health determinants within populations have a greater effect on anthropometric status of children than differences in population level health determinants in low- and middle-income countries (LMICs).
Aspirin comparable to rivaroxaban for extended venous thromboembolism prophylaxis following arthroplasty
Patients initially treated with rivaroxaban following total knee or hip arthroplasty experienced similar rates of venous thromboembolism (VTE) regardless of continued rivaroxaban use or switching to aspirin for extended VTE prophylaxis.
Patients presenting with ischemic stroke 6 to 16 hours after they were last known to be well had improved functional outcomes at 90 days if treated with thrombectomy and medical therapy compared to medical therapy alone.
No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography
Amongst patients undergoing angiography, neither sodium bicarbonate nor acetylcysteine were effective in preventing a composite outcome of death, need for dialysis, or persistent kidney injury.
No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.
In this study about quality of care for patients with TIA or minor stroke, there was substantial variation in adherence to guidelines for patients treated at Veteran's Affairs (VA) hospitals across the country.
Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality.
In patients with nocturnal symptoms of post-traumatic stress disorder (PTSD), prazosin did not significantly reduce nightmares or improve quality of sleep compared to placebo at 10 or 26 weeks.
National sudden unexpected infant death (SUID) rates had the steepest decline during the 1990 to 1998 study time period, followed by slower decline during 1999 to 2015.
A preoperatively diagnosed patent foramen ovale was associated with an increased risk of stroke within 30 days of non-cardiac surgery. With Evidence Rating Level: 2 (Good).