Intensive LDL-C lowering reduces mortality in patients with higher baseline LDL-C

April 20, 2018

In this systematic review and meta-analysis, more intensive compared with less itensive LDL-C lowering was associated with a greater reduction in risk of total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels.

SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for T2D

April 20, 2018

SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment.

Optimizing organ donations from overdose deaths may help address national organ shortage

April 19, 2018

U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs).

Centrifugal-flow pumps improve complication free survival compared to axial flow-pumps

April 19, 2018

Advanced heart failure patients randomized to receive centrifugal-flow pumps demonstrated higher rates of 2-year survival free of disabling stroke or reoperation to remove or replace their device compared to patients randomized to receive axial-flow pumps.

Medicare pre-ESRD care results in more dialysis initiation but also increased two-year mortality

April 18, 2018

Veterans receiving pre-end stage renal disease (ESRD) nephrology care in under the Medicare system were more likely to undergo dialysis and had a higher two-year mortality rate than veterans that received pre-ESRD care through the Department of Veteran's Affairs (VA).

Higher short-term mortality demonstrated for women compared with men after STEMI

April 18, 2018

In a modern cohort of patients with readily available primary percutaneous coronary intervention, woman experienced greater mortality rates then men following ST-elevation myocardial infarction.

Prevalence of cerebral palsy in preterm infants changes over time

April 17, 2018

In preterm infants followed over a 3.75-year study period, the overall prevalence of cerebral palsy (CP) decreased from 16% to 12%, the prevalence of severe CP decreased from 26% to 16%, but the prevalence of mild CP increased from 39% to 43%.

Inhibiting mitochondrial responses after intra-articular fracture slows progression of posttraumatic osteoarthritis

April 13, 2018

Intra-articular fractures (IAFs) often lead to posttraumatic osteoarthritis (PTOA) through mechanisms that involve mitochondria.

BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combo Tx metastatic colorectal CA

April 13, 2018

BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer.

Emergency department revisit rates underestimated among pediatric patients

April 12, 2018

Emergency department (ED) revisit rates among pediatric patients were shown to be underestimated by almost 20% when only revisits that occurred at the same hospital as the original visit were considered.