Fingolimod shows superior efficacy to interferon beta-1a in pediatric MS

September 21, 2018

Among pediatric patients with relapsing multiple sclerosis, fingolimod was associated with a lower annualized rate of relapse and lower incidence of new lesions identified on T2-weighted magnetic resonance imaging (MRI) compared to interferon beta-1a.

Tafamidis improves all-cause mortality in transthyretin amyloid cardiomyopathy

September 21, 2018

In a phase 3 randomized control trial, tafamidis was shown to have associations with greater reductions in all-cause mortality and cardiovascular related hospitalizations compared to placebo among participants with transethyretin amyloid cardiomyopathy.

Tailoring fecal immunochemical test thresholds by age, sex may aid CRC screening

September 19, 2018

Cancer detection among participants was higher with lower positivity thresholds.

Canakinumab administration tied to significant reduced risk for gout attacks

September 19, 2018

Canakinumab administration did not result in changes to serum uric acid levels.

Palliative care consultation tied to lower deaths by failed code resuscitation

September 19, 2018

Among deaths at one, large children's hospital, the most common mode of inpatient death was withdrawal of life sustaining technologies, followed by nonescalation of care during or at the time of death, and failed resuscitation (code).

Early language exposure predictive of language skills and IQ in school children

September 10, 2018

Language-based interactions between children 18 to 24 months of age and adults predicted intelligence quotient (IQ), verbal comprehension, and expressive and receptive language skills at 9 to 13 years old.

Designer opioid receptor agonist provides pain relief without side effects

September 08, 2018

Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia, dependence, and abuse.

Cost a key consideration of WHO guidelines for diabetes treatment intensification

September 06, 2018

WHO guidelines recommend selecting sulfonylureas as the single best second-line agent for Type 2 Diabetes Mellitus (T2DM) patients.

Despite guidelines, use of CT for head trauma in children remains unchanged

September 05, 2018

The Pediatric Emergency Care Applied Research Network (PECARN) published clinical prediction rules in 2009 to identify children with head trauma for whom computed tomography (CT) neuroimaging can be avoided.

Clinical guidelines may lead to better prescribing practices

August 30, 2018

Following clinical guidelines release, decreases were observed in the overall rate of opioid prescribing. 2. Guidelines may be associated with reduced high-dosage opioid prescriptions and the percentage of patients with overlapping benzodiazepine and opioid prescriptions.