Thromboembolic Disorders

Labeling for Several HIV Meds Updated to Include Interaction Data With DOACs

By August 14, 2018

If Tybost is given with atazanavir or darunavir, coadministration with rivaroxaban is not recommended due to a potentially increased bleeding risk.

Which Drugs Are Effective for Preventing Sudden Cardiac Death in HFrEF?

By August 01, 2018

For this study, researchers searched multiple databases for studies in which the effectiveness of various pharmacologic interventions were evaluated in patients with HFrEF.

Prehospital Plasma Cuts Mortality Risk in Hemorrhagic Shock

July 26, 2018

An early separation of the 2 treatment groups was observed with Kaplan-Meier curves; it began 3 hours after randomization and persisted until 30 days post-randomization.

Escitalopram Cuts MACE Risk in Depressed Patients With ACS

July 25, 2018

Higher risk of major adverse cardiac events with concurrent depression after acute coronary syndrome

FDA Warns Against Risks of Contaminated Synthetic Cannabis

July 23, 2018

Hundreds of individuals in about 10 states have been hospitalized in recent months after experiencing these complications and there have been several related deaths.

Results From Long-Term Cardiovascular Safety Study of Lorcaserin Announced

By July 19, 2018

Approximately 12,000 patients took part in the CAMELLIA-TIMI 61 trial in which participants were randomized to either lorcaserin HCl 10mg twice daily or placebo.

New Data Support Long-Term Cardiovascular Safety of Linagliptin in T2D

By July 19, 2018

Results showed the overall safety profile of linagliptin in study patients, including adults with kidney disease, was consistent with previous data.

Multivitamin/Mineral Supplementation and CVD Outcomes: Is There a Link?

July 12, 2018

The researchers found that there was no correlation between MVM supplementation and CVD mortality, CHD mortality, stroke mortality, or stoke incidence 1.02, 0.95, and 0.98.

Evidence Lacking for ABI for PAD Screen in Asymptomatic, Says USPSTF

July 12, 2018

"At this time, there is not enough evidence to recommend for or against using the ABI as a screening tool," Task Force member Seth Landefeld, MD, said in a statement.

Safety of Direct Oral Anticoagulants Versus Warfarin Investigated

July 11, 2018

Compared with warfarin, apixaban was correlated with reduced risk of major bleeding and intracranial bleeding (adjusted hazard ratios, 0.66 and 0.4, respectively) and dabigatran was correlated with reduced risk of intracranial bleeding (adjusted hazard ratio, 0.45) among patients with atrial fibrillation.

Transfeminine Persons Have Increased VTE Incidence

July 10, 2018

The researchers found that the incidence of VTE was higher for transfeminine participants, with 2- and 8-year risk differences of 4.1 and 16.7 per 1,000 persons, respectively.

High-Risk <i>APOL1</i> Not Tied to CVD, Stroke in Older Black Women

July 09, 2018

Carriers of high-risk APOL1 variants had increased incidence of hospitalized heart failure with preserved ejection fraction (HFpEF) compared with low-risk carriers after a mean of 11 years; no differences were seen for other outcomes.

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

By July 06, 2018

The retrospective cohort study involved a search of Medicaid claims of pediatric patients aged 5 to 20 years who were initiated on atypical antipsychotic medications.

Marriage May Protect Against Cardiovascular Disease

July 05, 2018

Association seen between marital status and risk, prognosis of coronary heart disease or stroke

Gastroprotective Effects of PPIs, H2RAs Compared in Patients on DAPT

By July 03, 2018

For this study, researchers searched several large databases (from 1980 to 2016) for randomized, controlled trials (RCTs) that compared clinical outcomes in patients on DAPT taking PPIs or H2RAs.

Coffee Drinking Found to Lower Risk of All-Cause Mortality

July 03, 2018

Similar findings across type of coffee, quantity, type of death, and caffeine metabolism score

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

July 02, 2018

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass

Genetic Risk, Lifestyle Predict CVD, Diabetes Independently

June 28, 2018

A total of 339,003 unrelated individuals of white British descent with available genotype and matching genetic data from the UK Biobank cohort study were included in the study.

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

By June 25, 2018

Data from large Phase 3 studies showed that treatment with rivaroxaban was found to be safe and effective in older patients.

Varicella Vaccination and Pediatric Arterial Ischemic Stroke: Is There a Link?

By June 20, 2018

The study authors reported that the rate of AIS in the 12 months following vaccination was 7.8 per 100,000 person-years at risk (95% CI: 4.8, 10.9) in patients who received the vaccine versus 6.8 (95% CI: 1.3, 12.2) in those who did not.

Increased Risk of MI, Ischemic Stroke After COPD Exacerbation

June 19, 2018

Greater risks were seen following a severe exacerbation (incidence rate ratios, 2.58 and 1.97 for myocardial infarction and ischemic stroke, respectivley) than after a moderate exacerbation (incidence rate ratios, 1.58 and 1.45, respectively).

Risk of CV Events Down With Med Diet Plus Olive Oil, Nuts

June 19, 2018

Participants who were at high cardiovascular risk were randomized to 1 of 3 diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet featuring advice to reduce dietary fat.

Good Sleep Tied to Better Cardiometabolic Health in Youths

June 15, 2018

"These results support the need to assess the role of sleep quantity and quality interventions as strategies for improving cardiovascular risk profiles of adolescents," the authors write.

Elevated NT-proBNP Found to Up Cardiovascular Risk in T2DM

June 15, 2018

NT-proBNP at baseline was independently linked to development of major CV events, in particular hospitalization for heart failure, after adjustment for potential confounders.

VTE Linked to Acute Decline in Physical Function in Women

June 15, 2018

Longer-term slopes of physical function decline did not differ for women with vs without VTE; however, the absolute level of physical function was worse at the end of follow-up for women with versus those without VTE.

Personalized Goals, Cash Motivate Heart Patients to Exercise

June 14, 2018

The researchers found that patients in the incentive arm had a significantly greater increase in mean daily steps from baseline during the ramp-up (P<.01), maintenance (P<.001), and follow-up (P<.01) phases.

Peri-Op RBC Transfusions Linked to Postoperative VTE

June 14, 2018

Perioperative RBC transfusion was correlated with increased odds of VTE, deep vein thrombosis, and pulmonary embolism (adjusted odds ratios, 2.1, 2.2, and 1.9, respectively), independent of various possible risk factors.

Teens 13&#43; Should Be Assessed for VTE Prophylaxis

June 12, 2018

Post-pubertal adolescents (about 13 years of age and older) have slightly elevated VTE risk, although the incidence is significantly lower than that in the adult population. These adolescents should be evaluated for prophylaxis; if other risk factors are present, intervention may be warranted.

New Coagulation Monitoring Device Allows for Wireless Reporting of INR Results

By June 11, 2018

The system is intended for properly selected trained users ≥22 years of age who have been stabilized on anticoagulation with vitamin K antagonists for ≥6 weeks.

Disparities for Risk of Recurrent Hemorrhagic Stroke Unexplained

June 07, 2018

The researchers found that of the survivors (1,121 white, 529 black, and 605 Hispanic), both black and Hispanic patients displayed higher systolic BP (SBP) during follow-up (P<.05).