Short Regimen Noninferior for Rifampin-Resistant Tuberculosis
A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides, according to a new study.
Tuberculosis
Stratifying by Severity May Allow Shorter TB Tx Regimens
The researchers found that a baseline smear grade of 3+ relative to <2+, HIV seropositivity and adherence of ≤90% were significant risk factors for an unfavorable outcome
Patient Develops Rare Extrapulmonary Manifestation of Tuberculosis
The patient, a 42-year-old female with systemic lupus erythematosus treated with mycophenolate mofetil and prednisone, reported swelling and pain in the fifth finger of her left hand for about 1-week.
MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse
The researchers found that the mean MIC of isoniazid below the breakpoint was 0.0334 ± 0.0085µg/mL and 0.0286 ± 0.0092µg/mL in the relapse and cure groups, respectively.
Rifampin Effective for Latent Tuberculosis in Children
Rifampin has advantage of being a shorter, single-drug regimen that is palatable for children
CDC: Updated Recommendations for Latent TB Infection Treatment
In 2017, a Work Group was assembled to conduct a systematic review of 3HP regimen studies published between January 2006 to June 2017, specifically looking at outcomes in children, individuals with HIV/AIDS, and those who self-administered treatment.
Decrease in U.S. Mortality From Infectious Diseases Seen in Last 3 Decades
A total of 113,650 deaths or a rate of 34.10 per 100,000 persons were due to infectious diseases in the United States in 2014, compared with 72,220 deaths or a rate of 41.95 deaths per 100,000 persons in 1980.
Unexpected Toxicities Identified With Concomitant HIV, Tuberculosis Tx Use
The study had to be cut short when 2 of 4 subjects developed serious toxicities following the third isoniazid-rifapentine dose.
Completion Likely With Self-Administration of TB Treatment
The researchers found that overall, treatment completion was 87.2% (95% confidence interval, 83.1 to 90.5%) in the direct observation group, 74% (95% confidence interval, 68.9 to 78.6%) in the self-administration group, and 76.4% (95% confidence interval, 71.3 to 80.8%) in the self-administration-with-reminders group.
Treatment Regimens for Latent Tuberculosis Infection Compared
Isoniazid, rifampicin monotherapy, combination therapies can prevent active TB in latent TB infection
