IV Vitamin C Increases Risk for Death, Organ Failure in Sepsis
Risk increased with intravenous vitamin C versus placebo for adults with sepsis in the ICU receiving vasopressor therapy
Sepsis
Hospital Fluid Culture and Outcomes in Patients With Sepsis, Septic Shock
To what extent does hospital fluid culture influence the mortality rates of patients with severe sepsis and septic shock?
Obesity Confers Longer Ventilator Use, Increased Risk for ARDS in Sepsis
In patients with sepsis admitted to the ICU who were classified as obese experienced longer durations of ventilator use and had a higher risk for ARDS compared with patients with a normal BMI.
High-Dose IV Vitamin C Does Not Speed Resolution of Septic Shock
Combination of vitamin C, hydrocortisone, thiamine not superior to usual care with hydrocortisone alone.
Statins Taken Before Septic Shock May Reduce ARDS Risk
Statin therapy before septic shock may decrease the risk for acute respiratory distress syndrome.
Nangibotide Gets Fast Track Status for Treatment of Septic Shock
The Food and Drug Administration (FDA) has granted Fast Track designation to nangibotide (LR12; Inotrem S.A.) for the treatment of septic shock. Nangibotide, a TREM-1 (triggering receptor expressed on myeloid cells-1) inhibitor, is a chemically synthesized peptide that acts as a decoy receptor interfering with the binding of TREM-1 and its ligand. Based on preclinical…
Dog’s Saliva Caused Bacterial Infection Leading to Amputations
Doctors diagnosed Manteufel with a rare blood infection caused by Capnocytophaga canimorsus, which is commonly found in the saliva of most healthy dogs and is usually not harmful to humans, the Post reported.
Giapreza Now Available to Up BP in Adults With Septic, Other Distributive Shock
Giapreza, a vasoconstrictor, increases blood pressure through increased aldosterone release
Does Adjunctive Steroid Tx Improve Outcomes in Patients With Septic Shock?
Death rates for the hydrocortisone group was not significantly lower than the placebo group; a total of 511 patients (27.9%) in the hydrocortisone group died compared to 526 (28.8%) in the placebo group (odds ratio, 0.85; 85% CI, 0.82 to 1.10; P=0.50).
Does Thiamine Supplementation Reduce Kidney Injury in Septic Shock?
Data on renal function, need for RRT, timing of hemodialysis catheter placement, and timing of RRT initiation were abstracted for 70 patients.
