The Effects of Rhinovirus in Children With Severe Wheeze
Can clinicians identify children who are at risk of developing a persistent wheeze?
Respiratory Infections
Shorter, Low-Dose Amoxicillin Feasible for Pediatric Community-Acquired Pneumonia
For children with CAP, lower-dose outpatient oral amoxicillin was noninferior to a higher dose and 3-day duration was noninferior to 7 days.
Amoxicillin Not Effective for Pediatric Lower Respiratory Tract Infection
Amoxicillin unlikely to be clinically effective overall or in specified clinical subgroups in whom antibiotics are commonly prescribed
Pneumococcal 15-Valent Conjugate Vaccine Immunogenic, Safe in Healthy Infants
The multicenter, randomized, double-blind, active-comparator-controlled phase 3 PNEU-PED study included 1720 healthy infants enrolled at 42-90 days of age.
Troubling Rise Seen in Both COVID-19, RSV Cases Among Children
Patients have ranged in age from 2 weeks to 17 years, and some have also had COVID-19 pneumonias
MPR Weekly Dose Podcast 83
This week the FDA approved a first-in-class switch for an antihistamine nasal spray, a new oral contraceptive, and Pradaxa was approved to prevent venous thromboembolism in pediatric patients. Also, we look at a published report on the real-world efficacy of the COVID-19 treatment remdesivir.
Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection
No differences seen in follow-up symptom severity for delayed versus immediate antibiotics or for delayed versus no antibiotics
ACP Offers Guidance on Antibiotic Duration for Common Infections
Best practices recommend limiting antibiotics to five days for COPD exacerbations, acute uncomplicated bronchitis
Real-World Data Show Tdap Vaccination During Pregnancy Reduces Infant Pertussis Risk
Tdap vaccination in the recommended 27–36-week window provides the largest benefit.
Trial Evaluating Dapagliflozin in Hospitalized COVID-19 Patients Misses Endpoints
The DARE-19 trial evaluated dapagliflozin in addition to standard of care in reducing disease progression, clinical complications and all-cause mortality in 1250 adults hospitalized with COVID-19.
