Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease
Two studies show lack of benefit in primary or secondary end points with cinpanemab or prasinezumab versus placebo
Parkinsonism
NDA Submitted for Continuous SC Infusion Therapy for Parkinson Disease
ABBV-951 is a solution of levodopa and carbidopa prodrugs for continuous subcutaneous infusion.
First Generic Version of Apokyn Drug Cartridges Gets FDA Approval
The approval is only for the drug cartridges, which are compatible for use with the Apokyn Pen, the brand name pen injector.
Supernus One Step Closer to Decision on Apomorphine Infusion Device
SPN-830 provides a continuous subcutaneous infusion of apomorphine through an infusion pump.
MPR Weekly Dose Podcast Episode 108
This week: in COVID related news, a heartburn medication shows benefits; Bebtelovimab is authroized; Veklury is shown to retain antiviral activity against variants. Away from COVID, a functionally scored carbidopa/levodopa tablet is now available for Parkinson disease, and the FDA issues an alert regarding ketamine compounding.
Functionally Scored Carbidopa/Levodopa Tablet Now Available for Parkinson Disease
The FDA approved Dhivy in November 2021 based upon bioavailability studies comparing Dhivy to an immediate-release tablet containing 25mg of carbidopa and 100mg of levodopa.
Dopamine Agonists, DRIs Similar for QoL in Parkinson Disease
No measurable difference in patient-rated quality of life seen for dopamine agonists versus dopamine reuptake inhibitors as adjuvant therapy
Novel Pramipexole-Rasagiline Combo Promising for Early Parkinson Disease
The fixed-dose combination therapy was found to be superior to each component.
AAN Updates Recommendations for Early Parkinson Disease Treatment
Counseling should be provided to individuals with early Parkinson disease on the benefits and risks of initiating treatment.
Focused Ultrasound Device Approved for Advanced Parkinson Disease
Patients are awake and responsive during the whole treatment duration.
