Vitamin D Deficiency Tied to Gestational Diabetes Risk
Association even stronger for women persistently deficient through the second trimester
Obstetrics and Gynecology
Combined Oral Contraceptive Pill, Metformin Assessed for PCOS Management
The use of combined oral contraceptive pills (COCP) and metformin, either as monotherapy or combined, was evaluated for the treatment of polycystic ovary syndrome (PCOS) in a recent systematic review published in the journal Clinical Endocrinology. Study authors systematically searched electronic databases for applicable randomized controlled trials that assessed these therapies for the management of…
NDA for Twirla Contraceptive Patch Resubmitted to FDA
Agile Therapeutics has resubmitted to the Food and Drug Administration (FDA) the New Drug Application (NDA) for its product, Twirla, an investigational low-dose combined hormonal contraceptive patch (AG200-15). Based on the results from a comparative wear study, the resubmitted NDA will address the FDA’s questions on in vivo adhesion, additional information on the Company’s manufacturing…
Benzodiazepine Use in Early Pregnancy Linked to Spontaneous Abortion
According to the results of a recently published nested case-control study, exposure to any benzodiazepine in early pregnancy may increase the risk of spontaneous abortion (SA).
Prophylactic Antibiotic Cuts Infection Risk After Operative Vaginal Birth
Benefits seen following operative vaginal birth at 36 weeks of gestation or later.
Quitting Smoking While Pregnant Tied to Reduced Risk for Preterm Birth
Risk reduced even for high-frequency cigarette smokers
Vitamin B Intake and Hip Fracture Risk: What’s the Link?
High intake of vitamin B6 and B12 may increase the risk of hip fracture in postmenopausal women, according to the results of a recently published prospective cohort study.
Relugolix Combination Therapy Effective in Phase 3 Uterine Fibroids Trial
A phase 3 study evaluating the safety and efficacy of relugolix (Myovant Sciences), an investigational oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in combination with estradiol 1.0mg and norethindrone 0.5mg in women with uterine fibroids, met its primary endpoint.
Progesterone Offers No Benefit for Bleeding in Early Pregnancy
Progesterone administered in first trimester does not result in significantly more live births
Nut Intake in First Trimester May Benefit Child Neurodevelopment
Children of mothers with the highest level of nut intake have better scores on cognitive tests
