Oral NaV1.8 Inhibitor Designated Breakthrough Therapy for Severe Acute Pain
The designation was based on data from two phase 2 proof-of-concept studies that evaluated VX-548 for acute pain following abdominoplasty or bunionectomy surgery.
Nonnarcotic Analgesics
Local Interventions Can Reduce Opioid Rx After Urologic Surgery
A systematic review and meta-analysis show direct interventions have a greater impact on opioid prescribing than indirect interventions
Novel Sciatica Treatment Provides Significant Pain Relief in Phase 3 Trial
SP-102 is a dexamethasone sodium phosphate viscous gel formulation that is administered by epidural injection.
Questions Remain About Safety of Aspirin Cessation in Older Adults
Findings inconclusive for subgroup analysis looking at safety of ceasing regular aspirin use without a clinical indication after age 70 years
Guidelines Issued for Managing Critically Ill Pediatric Patients
Guidelines address seven domains of care, including analgesia, sedation, delirium, and optimizing the environment
Link Between Analgesics, Incident Tinnitus Explored in Women
No increased risk for tinnitus seen with low-dose aspirin, but increase seen with moderate-dose aspirin for those younger than 60 years, NSAIDS, acetaminophen
MPR Weekly Dose Podcast Episode 107
This week: millions of courses of a COVID-19 oral antiviral was provided to the US government for distribution throughout the country; There’s a draft guidance for novel nonopioid analgesics; Possible strangulation warning for enteral feeding tubes; A new treatment has been approved for cold agglutinin disease; And a treatment is under review for HFrEF.
Various Strategies Used by US Adults to Manage Chronic Pain
54.7 percent used only nonopioid pain management strategies and 4.4 percent used opioids only
Opioid Rx Up, Non-Rx Therapy Down During the Pandemic
Nonpharmacologic therapy decreased, opioid prescribing increased for patients seeking treatment for pain management in 2020 versus 2019
Dexamethasone Injectable Gel Fast Tracked for Lumbosacral Radicular Pain
The designation is supported by data from the phase 3 C.L.E.A.R. trial.
