Narcotic Analgesics

Alcohol Use With Opioids Common Even Without Abuse Past

Alcohol or sedative use during chronic opioid therapy (COT) for non-cancer pain puts patients at risk for adverse events such as respiratory depression or sedation, and the risk of concurrent use of central nervous system (CNS) depressants is not limited to patients with a history of substance abuse.

Veterans With Mental Health Issues Receive More Opioids

Iraq and Afghanistan war veterans with mental health diagnoses, particularly posttraumatic stress disorder (PTSD), are more likely to receive prescription opioid medications for pain-related conditions, have higher-risk opioid use patterns, and have increased adverse clinical outcomes associated with opioid use, compared to veterans with no mental health diagnoses.

Model Predicts Death Due to Acetaminophen Overdose

Model for Acetaminophen-induced Liver Damage (MALD), a mathematical model that utilizes commonly obtained laboratory values, including overdose amount and time elapsed since overdose, is effective for predicting outcomes in patients with acute liver failure due to acetaminophen overdose.

Overdose Prevention Programs Using Opioid Antagonist

Naloxone, an opioid antagonist, is being used by at least 188 overdose prevention programs in the United States, but many states with high death rates due to heroin or other opioid overdose do not include naloxone distribution in their programs.