Oxcarbazepine Tied to Nontrauma Fracture in Children Aged 4 to 13 With Epilepsy
Initiating oxcarbazepine, but not levetiracetam, linked to increased incidence rate ratio for nontrauma fracture
Musculoskeletal Disorders
Tymlos Label Update Highlights Bone Building Mechanism of Action
The update is based on data from an open-label, single-arm histomorphometry study.
Osteoporosis Treatments Compared to Assess Effects on Bone Mineral Density
The network meta-analysis compared the effects of 9 osteoporosis drugs on BMD.
No Difference Between Early and Late Allopurinol Initiation for Acute Gout Flare
Researchers compared the time to complete resolution of acute gout flare between early and late allopurinol initiation.
MPR Weekly Dose Podcast Episode 92
This week we have news on pediatric influenza vaccine guidance; Moderna submit data for their COVID-19 booster dose; There’s new FDA warnings for some JAK inhibitors; Trudhesa nasal spray is approved; And the FDA places a clinical hold on a gene therapy for phenylketonuria.
mRNA COVID-19 Vaccines Immunogenic in Immunosuppressed Patients
Titers of anti-S IgG lower for patients with chronic inflammatory disease receiving glucocorticoids or B-cell depletion therapy
NAMS Updates Position Statement on Osteoporosis Management
Risk factor assessment can identify candidates for screening; nonpharmacologic measures appropriate for all postmenopausal women
FDA: New Warnings and Limitations Set for Certain JAK Inhibitors
The revisions are based on a completed review of a large randomized safety clinical trial, which included 4362 patients with rheumatoid arthritis.
Vitamin D Supplementation No Aid to Muscle Health
Review finds no beneficial effects on muscle function, strength, or mass
Oral Myosin Inhibitor Fast Tracked for Becker Muscular Dystrophy
EDG-5506 is a selective, small molecule myosin inhibitor designed to protect injury-susceptible fast skeletal muscle fibers.
