Treatment with the combination gel + oral doxycycline was associated with a 66.2% reduction in inflammatory lesions, a 58.7% reduction in non-inflammatory lesions, and a 62.6% reduction in total lesions at Week 12 vs baseline (P <.0001).
POEM scores didn’t meet minimal clinically important difference after adjustment for confounders
The decreases from baseline using visual analogue scale pruritus scores were statistically significantly larger with the 1- and 5-mg doses of serlopitant (P=.022 and .013, respectively) versus placebo at week 6.
Of those with allergic reactions, 32 patients exhibited significant deterioration of AD. Compared to nonresponders, responders showed significantly higher specific immunoglobulin E (IgE) levels to birch pollen and apple in addition to a higher prevalence of allergic rhinoconjunctivitis.
The researchers found that overall repigmentation was significantly higher in the patches treated with 5-fluorouracil compared with tacrolimus. Excellent improvement was seen in 48% of the 5-fluorouracil-treated patches versus 16% of tacrolimus-treated patches.
The FDA approval of Ilumya for the treatment of adults with moderate-to-severe plaque psoriasis was supported by data from the pivotal Phase-3 reSURFACE clinical development program.
Luzu, an azole antifungal, is indicated for the topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum.
Cosentyx is the first and only fully-human interleukin-17A (IL-17A) antagonist.
Cases of ulceration and necrosis have been reported with the administration of Kybella following injections that are too superficial.
