Immunomodulation With IVIG, Glucocorticoids Examined in MIS-C
Early outcomes of two large observational studies show mixed results for the efficacy of immunomodulation with IVIG, glucocorticoids, or both
Miscellaneous Respiratory Disorders
ACP Issues Guideline on High-Flow Nasal Oxygen for Respiratory Failure
HFNO suggested for initial or postextubation management of acute hypoxemic respiratory failure in hospitalized adults
Tocilizumab Preserves Lung Function in Early Systemic Sclerosis
Stabilization of lung function independent of the extent of quantitative radiographic interstitial lung disease or fibrosis at baseline
First US Trachea Transplant Patient Breathing Freely
So far, patient has not had any complications or signs of rejection
Xolair Approved for Adults With Nasal Polyps
The approval was supported by data from the phase 3 POLYP 1 (N=138) and POLYP 2 (N=127) trials evaluating the efficacy and safety of Xolair in adults with nasal polyps who had an inadequate response to nasal corticosteroids.
Antifibrotic Therapy Gets Orphan Drug Status for Systemic Sclerosis
ACE-1334 is a TGF-beta superfamily-based ligand trap designed to bind and inhibit TGF-beta 1 and 3 ligands.
ATS Issues Guideline on Home Oxygen Therapy for COPD, ILD
Long-term oxygen therapy strongly recommended for adults with COPD, ILD who have severe chronic resting hypoxemia
CDC Reports Cases of Multisystem Inflammatory Syndrome in Adults
Small data set indicates that adults with current or previous SARS-CoV-2 can develop hyperinflammatory syndrome.
Benralizumab Looks Promising in Nasal Polyps Trial
The 56-week OSTRO trial evaluated the efficacy and safety of benralizumab, an interleukin-5 antagonist, in 413 adult patients with severe nasal polyposis.
Dupixent Prefilled Pen Approval Provides Additional Administration Option
The FDA has approved a prefilled pen formulation of Dupixent (dupilumab; Sanofi and Regeneron), providing another option for administering the treatment.
