Potential Med Errors Prompt FDA Action on Vinca Alkaloid Labeling
Chemotherapy agents such as vincristine sulfate injection, vinblastine sulfate injection, and vinorelbine tartrate injection should only be prepared in IV infusion bags.
Lymphoma
Bispecific CAR-T Therapy Found to Have Promising Efficacy in Older Patients With R/R B-Cell NHL
The bispecific CAR-T therapy targets CD20 and CD19.
Response Rates in Phase 1 Studies of Hematologic Malignancies Improved Over Time
Response rates have improved as phase 1 studies shifted from chemotherapy to targeted agents for hematologic malignancies.
Novel Assay Precisely Quantifies CAR T Cells, Identifies Responders
A novel assay was shown to precisely quantify CAR T cells in circulation and distinguish responders from nonresponders.
Lenalidomide Plus Rituximab: Effective for Older Patients With R/R Indolent NHL
Investigators performed post hoc subgroup analyses by age in patients with relapsed/refractory indolent lymphoma from the MAGNIFY study.
Liso-Cel Demonstrated Promising Clinical Activity in R/R MCL
CAR-T therapy demonstrated promising antitumor activity with low rates of grade 3 or higher CRS and neurotoxicity among patients with MCL.
Axi-Cel Demonstrated Durable Clinical Benefit in Advanced-Stage, Indolent Non-Hodgkin Lymphoma
CAR-T therapy induced high CR rates among patients with indolent NHL subtypes, including follicular lymphoma and marginal cell lymphoma.
HSCT Found Potentially Curative for Some T-Cell Lymphoma Patients
A multicenter, retrospective study demonstrated higher PFS and OS rates with allogeneic transplant for relapsed/refractory TCL.
Azacitidine Plus CHOP Shows Promise for PTCL Subtype
The purpose of this study was to evaluate azacitidine in combination with CHOP in a PTCL population enriched for AITL.
Romidepsin Plus CHOP Fails to Improve PFS in PTCL
The addition of romidepsin to CHOP did not improve PFS over CHOP alone among patients with previously untreated PTCL.
