Continuous vs. Intermittent Vancomycin in Children with MRSA Infections
Differences in total daily dose, AUC24, and AUC24/MIC were the primary endpoints of the study. Secondary endpoints assessed adverse events.
Differences in total daily dose, AUC24, and AUC24/MIC were the primary endpoints of the study. Secondary endpoints assessed adverse events.
Dalbavancin is a lipoglycopeptide used to treat gram-positive pathogens that cause ABSSSI. In the study patients were randomized 1:1 to receive intravenous single- or 2-dose dalbavancin (1500mg IV or 1000mg on Day 1 and 500mg on Day 8).
CDI represent an “urgent threat”, but there are currently no FDA-approved drugs or vaccines to prevent infections.
Data was compiled from electronic records for patients aged 3 months to 18 years who were diagnosed with CAP between 2009 and 2013.
A total of 7 male, critically ill trauma patients with preserved renal function were included in the study and received 750mg of levofloxacin administered intravenously every 24 hours.