Omadacycline Non-Inferior to Linezolid in ABSSSI Patients With CKD
Omadacycline is a novel, broad-spectrum aminomethylcycline related to tetracyclines; the OASIS phase 3 trial investigated whether it was non-inferior to linezolid.
Diagnosis & Disease Information
Antacids May Increase Some Children’s Risk of C. diff Infection
Whereas epidemiological risk factors for CDI among adults are well known, data is limited for children.
Febrile Seizures Risk Compared With Inactivated Flu Vaccine, PCV13
Researchers assessed the risk of febrile seizures following inactivated influenza vaccine and pneumococcal conjugate vaccine-13 during 2013-14 and 2014-15 flu seasons.
Viral Failure Rates for Dolutegravir-Based vs. Other Guideline Regimens
Rates of viral failure were compared in HIV patients initiated on dolutegravir-based vs. other guideline recommended regimens in clinical care.
PCV13 and PPSV23 Administration: Does the Order Affect Immune Response?
Two sequential administration groups were compared by demonstrating the antibody response curve and the reverse cumulative distribution curve analyses by serotype.
Efficacy of High- vs. Standard-Dose Flu Vaccine Compared in Older Adults
For adults aged ≥65 years, seasonal flu epidemics pose significant disease burden annually and not many vaccines are specifically formulated for this patient population.
Long-Term Safety and Efficacy of TAF vs. TDF in Blacks and Non-Blacks
At baseline, the viral load, CD4 cell counts, renal laboratory parameters, and bone mineral density (BMD) were comparable between the 2 treatment arms for blacks and non-blacks.
Zostavax Vaccine Efficacy: A 12-Year Review
The researchers conducted the study because protection against herpes zoster has been “shown to wane with time” and effect sizes “can be imprecise”.
Appropriateness of Dx, Antibiotic Use in Pediatric Uncomplicated UTIs
Appropriate diagnosis was defined as confirmed UTI which included: pyuria, a positive urine culture, and lower urinary tract symptoms.
Early De-Escalation of Vancomycin + Pip/Tazo May Reduce AKI Risk
Researchers sought to determine whether or not antimicrobial de-escalation significantly affects AKI rates.
