Case Report Reveals Another Possible Side Effect of Kratom
According to the authors, this is the first report of kratom-induced hyperprolactinemia.
According to the authors, this is the first report of kratom-induced hyperprolactinemia.
Men should only be diagnosed with hypogonadism, says the new guideline, if they display symptoms of a testosterone deficiency and their measurements of total or free testosterone are unequivocally and consistently low.
The FDA’s Bone, Reproductive and Urologic Drugs Advisory Committee (BRUDAC) voted 6 in favor and 13 against the benefit/risk profile of Tlando (testosterone undecanoate) capsules.
For short term ibuprofen use the effects of compensated hypogonadism are reversible, however the researchers state how it is unknown whether these effects are reversible for long-term ibuprofen use.
The AAP Section for Endocrinology compiled a list of tests that parents and physicians should question.
The discontinuation is not due to the safety or efficacy of the drug but due to the the multiple manufacturers that currently provide supply to the U.S. market.
Endogenous androgens, including testosterone and dihydrotestosterone (DHT), are responsible for the normal growth and development of male sex organs and for the maintenance of secondary sex characteristics.
“Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing,” the authors write.
The researchers found that of the 72 subjects taking testosterone, at each visit significant increases in hemoglobin/hematocrit levels and BMI were recorded, as was a decrease in high-density lipoprotein level.
Perrigo has received final approval from the Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Testosterone Topical Solution, the generic version of Eli Lilly’s Axiron Topical Solution.