Stroke Risk Up With Serotonin Reuptake Inhibitor Use
Exposure to selective serotonin reuptake inhibitors (SSRIs) is associated with an increased risk of intracerebral and intracranial hemorrhage.
Hematologic Disorders
No Increase in ICU Death With HES for Fluid Resuscitation
Use of hydroxyethyl starch (HES) for fluid resuscitation in the intensive care unit (ICU) is not associated with increased 90-day mortality but does correlate with increased use of renal-replacement therapy.
Cell Saver Not Cost-Effective in Single-Level Lumbar Surgery
Use of intraoperative blood salvage (cell saver) is not cost-effective for adult patients undergoing single-level posterior lumbar decompression and fusion (PLDF) surgery.
Physical Activity Moderately Ups Bleed Risk in Hemophilia
There is a moderate but significant transient increased risk in bleeding following vigorous physical activity in children and adolescent boys with hemophilia.
Unsuspected PE Seldom Linked to Death in Cancer Patients
Unsuspected pulmonary embolism (UPE) is not associated with an increased risk of death in cancer patients when compared to patients without pulmonary embolism (PE).
Retinal Hemorrhage Pattern Can Predict Inflicted Brain Injury
In children under the age of 3, a high dot-blot count for retinal hemorrhages (RHs) is a strong predictor of inflicted traumatic brain injury (ITBI) rather than accidental traumatic brain injury (ATBI).
New Drug Reduces Strokes After Aneurysm Surgery
An investigational drug that disrupts neurotoxic signaling pathways is safe and effective in reducing strokes in patients undergoing surgery for a brain aneurysm.
Severe Anemia Linked to Poorer Heart Surgery Outcomes
Adults undergoing cardiac surgery who have moderate-to-severe preoperative anemia have significantly increased morbidity and mortality compared with non-severely anemic patients.
Phase 3 Trial Update of Eliquis for Prevention of Stroke and Systemic Embolism in Nonvalvular Atrial Fibrillation
Bristol-Myers Squibb and Pfizer announced that the reductions in stroke or systemic embolism, major bleeding and mortality demonstrated with Eliquis (apixaban) compared to warfarin (Coumadin; Bristol-Myers Squibb) in the Phase 3 ARISTOTLE trial were consistent across a wide range of stroke and bleeding risk scores in patients with nonvalvular atrial fibrillation; these were results from a subanalysis from the study.
New Transplant Platform Successful in Sickle Cell
Non-myeloablative conditioning with post-transplantation high-dose cyclophosphamide expands the donor pool for bone marrow transplantation for patients with sickle cell disease.
