Generic Version of Ferriprox Now Available
Deferiprone is indicated for the treatment of patients with transfusional iron overload due to thalassemia syndromes when current chelation therapy is inadequate.
Hematologic Disorders
Haegarda Approved for Pediatric Hereditary Angioedema
The expanded approval was based on data from the pivotal phase 3 COMPACT study and the COMPACT open-label extension study.
FDA Approves Nucala for Hypereosinophilic Syndrome
The FDA has approved Nucala (mepolizumab; GlaxoSmithKline) for the treatment of hypereosinophilic syndrome (HES) for 6 months or longer without another identifiable non-blood related cause of the disease in patients aged 12 years and older.
Factors Contributing to Darbepoetin Responsiveness in CKD
In a Japanese study, approximately 1 in 8 CKD patients with anemia failed to respond to darbepoetin alfa therapy.
MPR Weekly Dose Podcast Episode 51
This week we cover AstraZeneca and the swift decision to restart their COVID-19 vaccine candidate trial; Pfizer and BioNTech want to expand enrollment for their candidate vaccine trial; There’s the Janus kinase inhibitor that could help reduce recovery time; An investigative antiviral may ease strain on hospitalizations; Aortic aneurysm, dissection assessed with fluoroquinolones; And a retrospective study compared cardiac events with azithromycin and amoxicillin use.
Vadadustat Noninferior to Darbepoetin in CKD
Despite favorable efficacy data, the HIF-PHI failed to demonstrate noninferiority to the ESA in patients with CKD with respect to the primary MACE safety endpoint.
Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease
But no change in opioid use observed for those receiving medical marijuana certification
Label Mix-Up Prompts Recall of IV Amiodarone, Tranexamic Acid
Inadvertent administration may result in serious adverse events.
MPR Weekly Dose Podcast Episode 48
Treatment shows promise for patients who had pneumonia associated with COVID-19; A COVID-19 test that may have given inaccurate results; Neck gaiters as face masks may actually spread the virus; Drug applications are halted by the FDA; And Narcan has it’s shelf life extended. Also, we recap drug pipeline news from the past week.
FDA Wants More Data on Gene Therapy for Hemophilia A
The Agency requested that the Company provide substantial evidence from its phase 3 study demonstrating durable effect using annualized bleeding rate.
