The application is supported by data from 2 pivotal open-label, randomized phase 3 trials (SIOPEL 6 and ACCL0431), which compared the efficacy of sodium thiosulfate plus cisplatin to cisplatin alone for the prevention of cisplatin-induced hearing loss.
By using smartphone microphone, speaker to assess eardrum mobility, app can detect middle ear fluid
Overall, 14.2% of all children had audiometric notches and high-frequency hearing loss; 4.5, 7.6, and 2.1% fulfilled the criteria of a notch, high-frequency hearing loss, and both, respectively.
The Clinical Oncology Group Protocol ACCL0431 trial enrolled 125 pediatric patients newly diagnosed with a germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, osteosarcoma, or other malignancy.
Older age at menopause also appears to increase the risk
