Gout Archives - Page 2 of 9 - MPR


Allopurinol Dose Escalation for Gout Does Not Improve Mortality

There was an increase in all-cause mortality among dose escalators (hazard ratio, 1.08; 95% confidence interval, 1.01 to 1.17). Similar effect sizes were seen for incidence of cardiovascular-related deaths (hazard ratio, 1.08; 95% confidence interval, 0.97 to 1.21) and cancer-related deaths (hazard ratio, 1.06; 95% confidence interval, 0.88 to 1.27).

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Both High and Low Uric Acid Levels Tied to Higher Mortality

The researchers found that over the study period (2,060,721.9 person-years), 2020 participants died, with 287 cardiovascular disease (CVD)-related deaths and 963 cancer deaths. Both low and high uric acid levels were associated with increased all-cause, CVD, and cancer mortality.