General Rheumatology Archives - MPR

General Rheumatology

The course of clinical illness in SLE can range from subtle to dramatic and is determined by the interplay between susceptibility genes and environmental triggers. Researchers know that lupus autoantibodies are present up to five years prior to development of clinical disease, with onset occurring once genetic load is sufficient and immune triggers present themselves. Serologic presence of antinuclear antibodies (ANA) is widely considered the first and most appropriate confirmatory test for SLE,

Recognizing Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a long-term autoimmune disorder that may affect the skin, joints, kidneys, brain and other organs. Although factors such as sunlight, certain drugs and viral infections are known to trigger SLE, the underlying cause is not fully understood. Because SLE is uncommon – it currently affects approximately 40 to 50 persons…