Praluent Approved for Homozygous Familial Hypercholesterolemia
The approval was based on data from the phase 3 ODYSSEY HoFH trial, which evaluated Praluent in 69 adults with HoFH who were on other LDL-C-lowering therapies.
Dyslipidemia
Aspirin Overused, Statins Underused for CVD Prevention in Seniors
56.4 percent aged 75 years and older using statin for secondary cardiovascular event prevention; 45.3 percent taking aspirin for primary prevention
Evkeeza Approved for Homozygous Familial Hypercholesterolemia
The approval was based on data from the double-blind, placebo-controlled phase 3 ELIPSE HoFH trial.
Inclisiran Approval Held Up by Inspection-Related Issues
Inclisiran is a chemically synthesized small interfering RNA that targets proprotein convertase subtilisin-kexin type 9 (PCSK9) messenger RNA.
Evolocumab Cuts LDL-C in Pediatric HeFH Patients
The multicenter, double-blind, placebo-controlled HAUSER-RCT study assessed the efficacy and safety of evolocumab in 157 patients aged 10 to 17 years with HeFH.
Evinacumab Gets Priority Review for Homozygous Familial Hypercholesterolemia
Evinacumab is an investigational fully-human monoclonal antibody that binds to and blocks the function of angiopoietin-like 3 (ANGPTL3).
LDL-C Lowering Combo Therapy Nexlizet Now Available
Nexlizet (bempedoic acid and ezetimibe; Esperion) is now available for use as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Nexletol, a First-in-Class LDL-C Lowering Oral Therapy, Now Available
Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver.
Study Shows Evolocumab Significantly Reduces LDL-C in Adults With HIV
“This is the first phase 3 study to demonstrate that a PCSK9 inhibitor can effectively and safely reduce LDL-C in people living with HIV at risk for cardiovascular disease who have high cholesterol level despite statin treatment,” said Professor Franck Boccara, MD, PhD, cardiologist and primary study investigator.
AHA: Prescription Omega-3 Fatty Acids Effectively Lower Triglycerides
4 g daily EPA+DHA or EPA only effective and safe for use as monotherapy or in combination
