Digestive and Biliary Disorders Archives - MPR

Digestive and Biliary Disorders

Givlaari Approved for Acute Hepatic Porphyria

The Food and Drug Administration has approved Givlaari (givosiran; Alnylam) for the treatment of adults with acute hepatic porphyria (AHP). AHP is a rare, genetic disease characterized by episodic and potentially life-threatening attacks. The disease is comprised of 4 subtypes that result from genetic defects affecting the heme biosynthesis pathway in the liver; this causes…