Diarrhea Archives - MPR

Diarrhea

Persistent Diarrhea, Delirium, and Beefy Tongue: Is It Pellagra?

A recently published report describes the case of a female patient who developed pellagra, a disease caused by severe niacin deficiency rarely seen in the US.   The 62-year-old patient presented to the emergency department (ED) complaining of diarrhea that had persisted for 2 months and occurred about 8 to 10 times per day. Two months…

Nerlynx Labeling Updated to Include Data on Antidiarrheal Prophylaxis

The Food and Drug Administration (FDA) has approved a labeling supplement for Nerlynx (neratinib; Puma Biotechnology) to include safety information regarding neratinib-associated diarrhea.  Nerlynx is a kinase inhibitor indicated for the extended adjuvant treatment of adult patients with early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer, to follow adjuvant trastuzumab based therapy. The…