Reduced CDI Recurrence Observed With Investigational Microbiome Therapy
SER-109 contains purified bacterial spores of multiple Firmicute species obtained from the stool of healthy human donors.
Diarrhea
Microbiome-Based Therapy Looks Promising for Recurrent C difficile Infection
“These positive preliminary findings represent a major step forward towards bringing an innovative, non-antibiotic option to patients that may help restore their gut microbiome,” said Per Falk, Ferring’s President and Chief Science Officer.
Dificid Approved for C. difficile-Associated Diarrhea in Pediatric Patients
The FDA has approved Dificid (fidaxomicin) for the treatment of Clostridioides difficile-associated diarrhea in adult and pediatric patients aged 6 months and older.
Persistent Diarrhea, Delirium, and Beefy Tongue: Is It Pellagra?
A recently published report describes the case of a female patient who developed pellagra, a disease caused by severe niacin deficiency rarely seen in the US. The 62-year-old patient presented to the emergency department (ED) complaining of diarrhea that had persisted for 2 months and occurred about 8 to 10 times per day. Two months…
Nerlynx Labeling Updated to Include Data on Antidiarrheal Prophylaxis
The Food and Drug Administration (FDA) has approved a labeling supplement for Nerlynx (neratinib; Puma Biotechnology) to include safety information regarding neratinib-associated diarrhea. Nerlynx is a kinase inhibitor indicated for the extended adjuvant treatment of adult patients with early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer, to follow adjuvant trastuzumab based therapy. The…
Recommendations Developed for Evaluating Chronic Diarrhea
AGA recommends fecal calprotectin, lactoferrin for screening for inflammatory bowel disease
FDA Warns of “Cure-All” Products That Actually Contain Bleach
The FDA is warning consumers to stop using products known as Miracle or Master Mineral Solution, Miracle Mineral Supplement, MMS, Chlorine Dioxide Protocol, and Water Purification Solution due to numerous reports of significant health issues.
Rotavirus Vaccination Tied to Lower Risk for T1DM in Children
No association seen for partial vaccination and incidence of type 1 diabetes
Review Describes Dangers Associated With Loperamide Abuse
A recent review published in The Journal of Clinical Pharmacology discusses the antidiarrheal medication loperamide and its potential for abuse in patients looking to self-treat opioid withdrawal symptoms or to experience euphoric effects with large doses.
Coagulopathy Linked to Antidiarrheal Med Ingestion in Patient With Underlying Liver Disease
The study authors noted that the patient’s elevated PT suggested vitamin K-dependent coagulation factor inhibition.
