Pizensy Approved for Chronic Idiopathic Constipation
The FDA has approved Pizensy (lactitol; Sebela) for oral solution, an osmotic laxative, for the treatment of chronic idiopathic constipation (CIC) in adult patients.
Constipation And Bowel Cleansers
Clenpiq Approved for Pediatric Use in Colonoscopy Prep
The prescribing information for Clenpiq (sodium picosulfate, magnesium oxide, and anhydrous citric acid; Ferring) has been updated to include use in pediatric patients ≥9 years old for cleansing of the colon as a preparation for colonoscopy. Previously, the treatment had only been approved for adult use. Clenpiq is a combination of sodium picosulfate, a stimulant…
DocuSol Kids Available OTC for Children With General Constipation
DocuSol Kids has been made available by Alliance Labs for the over-the-counter (OTC) treatment of general constipation in children 2–12 years of age. Each DocuSol Kids mini-enema (5mL) contains a delivered dose of docusate sodium 100mg in a polyethylene glycol base. The soft flexible tip allows for easy rectal usage under adult supervision. According to…
Motegrity Approved for Chronic Idiopathic Constipation in Adults
Shire announced that the Food and Drug Administration (FDA) has approved Motegrity (prucalopride) tablets for the treatment of adults with chronic idiopathic constipation (CIC).
FDA Panel Votes on Prucalopride for Chronic Idiopathic Constipation
The panel’s decision was made based on data from from five Phase 3 studies and one Phase 4 trial which evaluated the safety and efficacy of prucalopride in patients with chronic constipation.
AGA: New Opioid-Induced Constipation Management Guidelines Available
The recommendations have been published in the AGA’s official journal, Gastroenterology.
Tenapanor NDA Submitted for Irritable Bowel Syndrome With Constipation
Tenapanor, a minimally-systemic small molecule, inhibits the sodium transporter NHE3 and reduces sodium absorption in the gastrointestinal tract, thus increasing intestinal fluid.
New Bowel Prep Option for Colonoscopy Gets FDA Approval
The approval of Plenvu was based on multiple clinical trials including the NOCT study which compared Plenvu to the trisulfate bowel cleansing solution Suprep (sodium sulfate, potassium sulfate, magnesium sulfate oral solution; Braintree Laboratories) using a 2-day evening/morning split-dosing regimen.
FDA Accepts NDA for Novel Chronic Idiopathic Constipation Treatment
If approved, prucalopride will be the only readily available 5-HT4 agonist for adult CIC in the U.S.
Treatment With Homemade Enema Leads to Colitis in Two Children
A national survey showed that only about 7% of consumers read warning labeling on over-the-counter products.
