Oral Semaglutide NDAs Seeking T2D Indication, CV Risk Reduction
Novo Nordisk has submitted 2 New Drug Applications (NDAs) for oral semaglutide as well as a supplemental NDA (sNDA) for subcutaneous (SC) semaglutide (glucagon-like peptide-1; Ozempic).
CHF and Arrhythmias
FDA Approves New Valsartan Product Following Major Recall
The Food and Drug Administration (FDA) has approved a new generic version of Diovan (Novartis) that does not contain N-nitrosodimethylamine (NDMA) or N-nitrosodiethylamine (NDEA), 2 potentially carcinogenic impurities identified in several recalled valsartan products.
Prasugrel Compared With Ticagrelor in Patients With ACS Undergoing PCI
A systematic review and meta-analysis published in the American Journal of Cardiovascular Drugs compared the safety and efficacy of prasugrel and ticagrelor in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
Diuretic Use Differences Examined in HFrEF Patients Treated With Sacubitril/Valsartan, Enalapril
For patients with heart failure with reduced ejection fraction (HFrEF), treatment with sacubitril/valsartan may aid in reducing the requirement for loop diuretics compared with enalapril, according to the results of a follow-up analysis of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) trial.
Eating Nuts Tied to Reduced CVD Incidence, Death in T2DM Patients
Reduced risk seen for total CVD, coronary heart disease incidence for men and women
Rising Temps May Up Burden of Congenital Heart Disease in US
Projected increases in maternal heat exposure may result in increased congenital heart defect (CHD) burden.
AHA: Nearly Half of US Adults Have Cardiovascular Disease
These data “hold us accountable and help us chart our progress and determine if and how we need to adjust our efforts,” Mariell Jessup, MD, chief science and medical officer of the American Heart Association, writes in an accompanying editorial.
Long-Term Incidence of A-Fib Increased in Women With Breast Cancer
Breast cancer was associated with an increased incidence of AF during the first 6 months and from 6 months to 3 years for patients younger than 60 years (hazard ratios, 2.1 [95% confidence interval, 1.25 to 3.44] and 1.8 [95% confidence interval, 1.38 to 2.35], respectively).
Infective Endocarditis Related to Injection Drug Use Rising
The risk for infective endocarditis related to injection drug use increased from 2006 to 2015, according to a study published online January 28 in CMAJ, the journal of the Canadian Medical Association.
Meta-Analysis: Aspirin Linked to Lower Risk for CV Events in Primary Prevention
For individuals without cardiovascular disease, use of aspirin is associated with a reduced risk for cardiovascular events and an increased risk for major bleeding, according to a newly published meta-analysis.
