Vitamin D Supplement Does Not Reduce Fracture Risk in Older Adults
Among adults not selected for vitamin D deficiency, low bone mass, or osteoporosis, no effect seen on total, nonvertebral, or hip fracture risk
Bone Disorders
Fracture Risk Up With Insulin Compared With Metformin in T2DM
Risk for major osteoporotic fractures up for insulin versus metformin for those with HbA1c <7 percent, BMI <25 kg/m2
Meta-Analysis: Smoking Linked to Increased Fracture Risk for Men
Increased risk seen using frequentist approach and Bayesian approach; significant association also seen in subgroup analyses
ALK-2 Inhibitor Fast Tracked for Fibrodysplasia Ossificans Progressiva
BCX9250 is an investigational activin receptor-like kinase-2 (ALK-2) inhibitor designed to stimulate normal bone growth and renewal.
Gentamicin-Eluting Bone Graft Substitute Gets FDA Clearance
Cerament G is a resorbable, gentamicin-eluting ceramic bone void filler.
NSAIDs May Interfere With Efficacy of Bisphosphonates
No reduction in osteoporotic fracture risk seen among women receiving concomitant clodronate and NSAIDs
Hip Fracture Risk Up With Drug Holiday From Risedronate vs Alendronate
After 3 or more years of therapy, drug holidays from risedronate versus alendronate linked to 18% increase in hip fracture risk
Prevalence of Fragility Fractures Up With E-Cigarette Use
Among U.S. adults, prevalence of fragility fractures increased for former and current e-cigarette users compared with never users
Voxzogo Gets FDA Approval for Achondroplasia
The approval was based on data from a phase 3 study that evaluated the efficacy and safety of Voxzogo in 121 children with genetically-confirmed achondroplasia.
Fracture Risk Assessed Among Users of SGLT-2 Inhibitors vs Other Antidiabetic Agents
The study authors conducted a nationwide cohort study that included 137,667 Medicare beneficiaries.
