Incidence of Parkinson Disease Increased in Bipolar Disorder
High frequency of psychiatric admissions for manic/mix, depressive episodes linked to increased risk for PD
Diagnosis & Disease Information
Concomitant Use of Lithium and Antipsychotics May Be Neurotoxic
Concomitant use of lithium and antipsychotics, particularly haloperidol, may be associated with neurotoxicity in some patients.
Kidney Disorder Risk Examined Among Various Bipolar Disorder Drug Regimens
According to the results of a retrospective observational study, the majority of pharmacotherapies used for the treatment of bipolar disorder (BD) are associated with some risk of kidney disorder (KD).
Results From Bipolar I Disorder Trials Evaluating Brexpiprazole Announced
Data from two Phase 3 studies evaluating brexpiprazole for the treatment of patients with manic episodes associated with bipolar I disorder did not meet the primary endpoint of statistical separation from placebo as measured by the Young Mania Rating Scale (YMRS) at week 3.
Oral Therapy for Suicidal Bipolar Depression Gets Breakthrough Designation
NRX-101 combines D-cycloserine (DCS), an N-methyl-D-aspartate (NMDA) receptor antagonist, and lurasidone, a D2/5-HT2a receptor antagonist.
FDA to Review Vraylar sNDA for Treatment of Bipolar Depression
The sNDA included findings from the RGH-MD-53, RGH-MD-54, and RGH-MD-56 trials in which cariprazine was associated with greater improvement in change from baseline to week 6 on the Montgomery Asberg Depression Rating scale (MADRS) total score vs placebo in bipolar I patients.
Many Foster Kids Inappropriately Prescribed Psychiatric Drugs
A report from the Department of Health and Human Services (HHS) found that 1 in 3 foster children sampled in 5 states received the drugs without treatment plans or follow-up.
Treating Older Adult Bipolar Disorder: Newer Atypical Antipsychotics Compared
While pharmacologic agents such as lithium and valproic acid have been shown to provide significant antimanic effects in older adults with bipolar disorder, an increase in the use of atypical antipsychotics in the general adult bipolar population prompted researchers to investigate the efficacy and tolerability of these agents in OABD.
Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder
With regard to safety, treatment with lithium in this patient population was considered “generally safe, at least in the short term.”
Case: Hypertensive Crisis Following Use of Armodafinil + MAOI
This case involved a 36-year-old female with bipolar disorder who presented to the emergency department (ED) with blurry vision, neck stiffness and the “worst headache of (her) life” after taking armodafinil with tranylcypromine.
