Seizure Disorders

Adjuvant Cannabidiol Examined for Seizure Reduction in Pediatric-Onset Epilepsy

March 07, 2018

Researchers found for one person using CBD to experience a 50% or greater seizure reduction, the number needed to treat was 8.

Prenatal Valproate Exposure May Impact Offspring School Performance

February 21, 2018

The researchers found that children exposed to valproate scored worse on the sixth-grade Danish tests (adjusted difference, −0.27 standard deviation [SD]) and sixth-grade mathematics tests (adjusted difference, − 0.33 SD) .

Influenza vaccine not associated with increased risk of epilepsy in children

February 15, 2018

No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.

FDA Clears Smart Watch for Epilepsy Management

By February 06, 2018

Embrace uses advanced machine learning to monitor for grand mal or generalized tonic-clonic seizures, and sends an alert to summon caregivers' help.

Cannabidiol Effective for Treatment-Resistant Lennox-Gastaut Syndrome

January 25, 2018

"Add-on cannabidiol is efficacious for the treatment of patients with drop seizures associated with Lennox-Gastaut syndrome and is generally well tolerated," the authors write.

Impact of Maternal Folate Status on Child's Autistic Traits After AED Exposure

By December 28, 2017

Children exposed to antiepileptic drugs (AEDs) in utero may have a reduced risk of autistic traits with periconceptional folic acid supplementation and folate status

More Than a Third of Patients Do Not Respond to Antiepileptics

December 28, 2017

Overall, 89.9% of patients who achieve seizure control do so with first, second AED regimen

Epidiolex Under Review for Two Childhood-Onset Epilepsy Conditions

By December 28, 2017

Epidiolex is a pharmaceutical formulation of purified cannabidiol

Enzalutamide Seizure Risk Factor Assessed in mCRPC

December 08, 2017

Within 4 months of enzalutamide initiation, four patients (1.1%) had at least one confirmed seizure; three additional patients (0.8%) experienced a seizure within four months following the 4-month study period.

Later Seizure Disorder Risks Assessed Following Eclampsia

November 10, 2017

After a pregnancy with eclampsia, a future seizure disorder was significantly more likely (4.58/10,000 person-years) compared with a pregnancy without a hypertensive disorder of pregnancy (0.72/10,000 person-years; crude hazard ratio [HR], 6.09).

Vimpat Approved to Treat Partial-Onset Seizures in Children

By November 06, 2017

Clinicians can prescribe Vimpat to their pediatric patients either as an oral solution or a tablet.

Role of Medical Cannabinoids Investigated for Children

October 23, 2017

"Additional research is needed to evaluate the potential role of medical cannabinoids in children and adolescents, especially given increasing accessibility from state legalization," write the authors.

Novel Vagus Nerve Stimulation Device Approved for Drug-Resistant Epilepsy

By October 10, 2017

The system includes a detect-and-respond mode, which is designed to prevent seizures before they start and deliver therapy to stop them if they do.

Suicidal Ingestion Outcomes Compared Between Bupropion and TCAs

By September 26, 2017

Results showed that bupropion users were more likely to have a seizure, have accompanied tachycardia on presentation, and be admitted to the hospital, compared to those who ingested a TCA.

Briviact Approved as Monotherapy for Partial-Onset Seizures

By September 15, 2017

The sNDA submitted to support the monotherapy indication included clinical data involving over 2,400 adults with partial-onset seizures.

Aptiom Gains Expanded Pediatric Seizure Indication

By September 14, 2017

The efficacy and safety of Aptiom as monotherapy and adjunct therapy for adults with POS was previously established in 5 multicenter, randomized, controlled studies. This data also supported the safety and tolerability of Aptiom for the treatment of pediatric patients with POS.

Do Antiepileptic Treatments Affect Fetal Growth, Preterm Delivery?

September 11, 2017

Increased risk for women on AEDs for epilepsy or other indications; risk varies with drug used.

Does Antiepileptic Drug Use Contribute to Adverse Pregnancy Outcomes?

By August 14, 2017

Women with epilepsy were at increased risk of adverse pregnancy and delivery outcomes.

How Prevalent Is Epilepsy in the United States?

August 14, 2017

Increases in the number of persons with active epilepsy were indicated based on National Health Interview Survey data from 2010 to 2015, probably due to population growth.

Brexanolone Examined in Super-Refractory Status Epilepticus

August 09, 2017

The response end point of weaning successfully off TLAs before tapering brexanolone was met by 17 patients (77%).

Interactions Identified Between Cannabidiol, Antiepileptic Drugs

August 08, 2017

The researchers observed significant increases in topiramate, rufinamide, and N-desmethylclobazam and a significant decrease in clobazam serum levels with increasing cannabidiol dose.

Antiepileptic Drugs Compared for Partial Onset, Generalized Seizure Types

August 02, 2017

The researchers found that for individuals with partial seizures, levetiracetam performed statistically significantly better than carbamazepine and lamotrigine for time to withdrawal of allocated treatment.

Angioedema Risk Evaluated for Levetiracetam Versus Phenytoin

By July 25, 2017

"The results suggest that levetiracetam has the same or lower risk for angioedema than phenytoin," wrote the researchers.

Seizure Drug Discontinued Due to Limited Use

By July 11, 2017

Potiga, a potassium channel opener, was approved in 2011 as an adjunctive treatment for partial-onset seizures in patients with inadequate response to alternative treatments.

FDA Expands Age Range for VNS Device in Drug-Resistant Epilepsy

By June 29, 2017

Study patients reported a 50% reduction in seizure severity as well as an improvement in mood among 49% of patients. Improvements in memory and achievement were seen in 38% and 39% of patient, respectively. Moreover, patients reported a 64% reduction in seizure worry.

Novel Liquid Soln for Lennox Gastaut Syndrome Gets Orphan Drug Status

By June 22, 2017

The Company is awaiting top-line results of the current trial before initiating the LGS study.

Valproic Acid Monitoring Necessary with Ketogenic Diet

June 22, 2017

The researchers found that the serum concentrations of carbamazepine, lamotrigine, levetiracetam, topiramate, and valproic acid decreased after the dietary therapies.

Cannabidiol Oral Solution Studied in Drug-Resistant Seizures

By May 26, 2017

The data showed a reduction in the median frequency of convulsive seizure per month from 12.4 to 5.9 with cannabidiol vs. a reduction from 14.9 to 14.1 with placebo.

Fatal Outcome for Patient after Nasal Insufflation of Antidepressant

By May 22, 2017

A 45-year-old man with a past history of IV drug use was found to be insufflating bupropion at his rehabilitation facility.

Aptiom sNDA for Pediatric Indication Accepted for Review

By May 22, 2017

The sNDA submission includes data from five controlled clinical trials in adults with POS and three clinical studies demonstrating safety and tolerability in pediatric patients.