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About 31% of patients with recalcitrant alopecia areata totalis or universalis had complete hair regrowth.

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application (NDA) for ADX-2191 (methotrexate injection) for the treatment of primary vitreoretinal lymphoma, a rare, aggressive retinal cancer. ADX-2191 is a preservative-free, intravitreal formulation of methotrexate designed to be vitreous-compatible. The application is supported by safety data from the phase 3…

When restricting analysis to patients with psoriasis, methotrexate was only associated with basal cell carcinoma

ADX-2191 is a preservative-free, intravitreal formulation of methotrexate designed to be vitreous-compatible.

Rates of tophus resolution increased in patients in both groups between week 24 and week 52, suggesting that the therapeutic benefits of pegloticase and MTX may extend beyond 6 months.

All participants’ responses were linked to their most recent semiannual questionnaire with regard to demographics, primary diagnosis, and patient-reported outcomes.

Investigators report findings from the MIRROR RCT trial, which compared pegloticase plus methotrexate vs placebo for uncontrolled gout.

Olokizumab superior to placebo and noninferior to adalimumab in producing ACR20 response at 12 weeks

Researchers evaluated the cardiovascular safety of hydroxychloroquine vs methotrexate among patients with rheumatoid arthritis.

The expanded approval was based on data from the phase 4 MIRROR trial, which evaluated Krystexxa plus methotrexate in 152 adults with uncontrolled gout.