Ketamine HCl 10mg/mL, 50mg/mL, 100mg/mL; soln for IM or IV inj.
Most studies supporting ketamine's benefit assessed efficacy during the first week following a single infusion; emerging studies indicate that repeated dosing may extend the efficacy for at least several weeks.
Patients who underwent multiple consecutive days of outpatient ketamine infusion for chronic neuropathic pain had minimal side effects and stable hemodynamics, a retrospective chart review presented during the 2012 American Academy of Pain Medicine Annual Meeting found.
When first- and second-line drugs fail in the treatment of refractory migraine, ketamine may be a suitable option. Natalie H. Strand, MD, Chief Medical Officer at Freedom Pain Hospital, Scottsdale, Arizona, reviewed the diagnostic criteria for migraine, clinical presentation of migraine, ketamine pharmacology, and the clinical application of ketamine for migraine for attendees at PAINWeek 2014.
The ketamine-treated patients demonstrated a clinically significant reduction in suicidal thoughts compared to the midazolam-treated patients within 24 hours (4.96 points greater reduction in SSI, 95% CI: 2.33, 7.59).
Compared with the active placebo, the infusions of ketamine were relatively well tolerated, except for greater dissociative symptoms and transient blood pressure elevations with the higher doses.
According to a meta-analysis published in Pediatric Drugs, ketamine was not associated with a postoperative opioid-sparing effect.
A new case study describes a 2 1/2-year-old girl with 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHAD) and stable hypertrophic cardiomyopathy who experienced ketamine-induced diabetes insipidus.
Using subcutaneously administered ketamine in a dose-escalating regimen as an adjunct to opioids and standard co-analgesics does not have any clinical benefit in relieving cancer pain, but it is associated with increased toxicity
Procedural sedation with propofol accelerates patient management in emergency departments, and saves time in comparison with midazolam/ketamine sedation.