Although valganciclovir is an effective CMV prophylactic agent after kidney transplantation, it is associated with significant side effects.
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Longer therapy with oral valganciclovir may modestly improve long-term developmental outcomes and hearing in neonates with symptomatic congenital cytomegalovirus (CMV) disease, reports a study in the New England Journal of Medicine.
For patients with glioblastoma, treatment with valganciclovir is associated with improved survival.
Letermovir is currently marketed under the brand name Prevymis for prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic HSCT.
The new approvals include Besremi, Fyarro, Livtencity, Voxzogo, and Vuity.
Livtencity is an orally bioavailable anti-CMV compound that targets and inhibits the UL97 protein kinase and its natural substrates.
Maribavir is an orally bioavailable anti-CMV compound that targets and inhibits the UL97 protein kinase and its natural substrates.
Ganciclovir 0.15%; ophthalmic gel; contains benzalkonium chloride.
Valganciclovir (as HCl) (prodrug of ganciclovir) 50mg/mL; pwd for reconstitution; tutti-frutti flavor.
Ganciclovir sodium 500mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution.