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The FDA has reviewed clinical trial data examining the risk of atrial fibrillation associated with bisphosphonate use.

The FDA has announced the possibility of severe and sometimes incapacitating bone, joint, and/or muscle pain in patients taking bisphosphonates.

The FDA has notified healthcare professionals that it is performing a review of data from published studies to evaluate if oral bisphosphonate drugs are associated with an increased risk of cancer of the esophagus.