Apixaban 2.5mg, 5mg; tabs.
The researchers found the risk of GI bleeding was lower for apixaban versus dabigatran or rivaroxaban.
While the use of NSAIDs was low in the ARISTOTLE trial, NSAID users had a higher risk for bleeding than non-users.
Lower rates seen for ischemic stroke or systemic embolism, GI bleeding or intracranial hemorrhage.
Different factor concentrates can reverse some of the alterations in hemostasis attributed to apixaban.
Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic cancer, is safe and well tolerated.
Older patients, females, and those with comorbidities were more likely to be on multiple medications.