Despite trend toward lower stroke risk with high dose
The FDA has approved the expanded indication for Kcentra (Prothrombin Complex Concentrate [Human]; CSL Behring) to include the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy in adult patients needing an urgent surgery or other invasive procedure.
Bristol-Myers Squibb and Pfizer announced that the FDA has approved Eliquis (apixaban tablets) to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF).
To compare the incidence of hospitalization for upper GI tract bleeding, researchers used US Medicare beneficiary files to identify a cohort of patients that were ≥30 years old who initiated oral anticoagulation therapy with apixaban, dabigatran, rivaroxaban, or warfarin, with or without PPI cotherapy.
Background- During long-term anticoagulation in atrial fibrillation, temporary interruptions (TIs) of therapy are common, but the relationship between patient outcomes and TIs has not been well studied. Methods and Results- In the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition …
A prospective phase 2 study of the low-molecular-weight heparin (LMWH) tinzaparin for initial treatment and secondary prophylaxis of venous thromboembolism (VTE) associated with cancer treatment found the agent to be safe and efficacious, with the recurrent VTE event rate comparing favorably with that reported for another LMWH, dalteparin according to a study presented at the 52nd American Society of Hematology Meeting and Exposition.
VKA, LMWH tied to lowest risk of adverse maternal, fetal outcomes, respectively
The FDA has notified healthcare professionals that it is evaluating post-marketing reports of serious bleeding events in patients taking Pradaxa (dabigatran etexilate mesylate; Boehringer Ingelheim).
Most U.S. patients with myocardial infarction (MI) are discharged on high-dose aspirin, but there is considerable variation across hospitals in proportion prescribed aspirin at discharge and in dosage.
Key classes of cardiovascular medications are affected by marijuana, including statins, β-blockers.