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Hereditary angioedema
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Generic Name and Formulations:

C1 esterase inhibitor (recombinant) 2100 IU; per vial; lyophilized pwd for IV inj after reconstitution; preservative-free.

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Indications for RUCONEST:

Treatment of acute attacks in adult and adolescent patients with hereditary angioedema (HAE).

Limitations Of use:

Efficacy not established in hereditary angioedema (HAE) patients with laryngeal attacks.


Give by slow IV inj over 5 mins. <84kg: 50 IU/kg. ≥84kg: 4200 IU. Max 4200 IU/dose. May give second dose if attack symptoms persist; max 2 doses/24hrs.


Not established.


Allergy to rabbits or rabbit-derived products.


Discontinue if hypersensitivity reactions occur. Monitor patients with known risk factors for thrombotic events (eg, indwelling venous catheter, history of thrombosis, atherosclerosis, morbid obesity, immobility). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

C1 inhibitor.


Risk of thrombotic events with concomitant oral contraceptives or certain androgens.

Adverse Reactions:

Headache, nausea, diarrhea; thrombotic events, hypersensitivity reactions (may be severe).

How Supplied:

Single-use vial—1