Respiratory And Thoracic Cancers
The integrated risk prediction model combining smoking exposure with the biomarker score yielded an area under the curve of 0.83 versus 0.73 for a model based on smoking exposure alone.
"In the case of BBQ fumes, dermal absorption was a more important pathway for intake of low-molecular-weight PAHs than inhalation," the authors write.
A Phase 2 multicenter trial examined the safety and efficacy of lurbinectedin in several types of advanced solid tumors, including SCLC.
Unlike most lesion medical image datasets currently available, which can detect only 1 type of lesion, DeepLesion has much diversity and contains critical radiology findings from across the body, including lung nodules, liver tumors, and enlarged lymph nodes.
Infugem utilizes a novel technology that enables cytotoxic oncology products to be premixed in a sterile setting and to be supplied to prescribers in RTA infusion bags.
Timely review and appropriate follow up on all patient reports is essential and must be part of a practice's routine.
Only 20% of the patients who died by suicide had a palliative care encounter, compared with 57% among lung cancer patients whose cause of death was not suicide.
The researchers found that more than 50% of the 3,055 nonsynonymous mutations detected across 122 evaluable patients with lung cancer were detected in WBC consistent with clonal hematopoiesis.
The researchers found that 13.7 and 4.9% of patients were still on pembrolizumab and were on pemetrexed maintenance, respectively, after a median follow-up of 12.8 months.
"Our findings demonstrate the heterogeneity of response to radiation in ATC tumors and superiority of hypofractionated RT in improving local control, metastatic spread, and survival in preclinical models," the authors write.
"Identifying circumstances in which LDCT screening is more versus less preference-sensitive may help clinicians personalize their screening discussions, tailoring to both preferences and clinical benefit," the authors write.
The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030, with prostate and lung cancer projected to be the most common cancer types.
Results showed that progression-free survival (PFS), the primary endpoint, was significantly longer in Tagrisso-treated patients vs EGFR tyrosine kinase inhibitor-treated patients (18.9 months vs 10.2 months; hazard ratio [HR] 0.46, 95% CI: 0.37, 0.57; P <.0001).
The researchers identified 168 prescriptions associated with HNCA and 571 with LCCA diagnoses. Compared to patients with LCCA, patients with HNCA had significantly increased odds of being prescribed an opioid (odds ratio, 1.68).
Compared with hot tea drinking alone, hot tea drinking combined with either alcohol consumption or smoking was associated with increased risk for esophageal cancer.
"These results indicate that nicotine nitrosation occurs in vivo in mice and that e-cigarette smoke is carcinogenic to the murine lung and bladder and harmful to the murine heart," the authors write.
To determine if a patient is eligible for Gilotrif, physicians must conduct biomarker testing to determine the type of EGFR mutation present.
In terms of early lung cancer death per individual screened, targeting lung cancer mortality risk may improve lung cancer screening efficiency.
Osimertinib improves progression-free survival in EGFR-mutated non-small-cell lung cancer: The FLAURA trial
Osimertinib demonstrated a significantly longer duration of progression-free survival compared to standard of care epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) in patients with untreated EGFR-mutated locally-advanced or metastatic non-small-cell lung cancer (NSCLC).
The researchers found that over four years, 299 patients developed a basal cell carcinoma end point and 108 developed a squamous cell carcinoma end point.