Psychiatric Disorders

KarXT is an oral, investigational therapy that combines xanomeline, a muscarinic agonist, and trospium chloride, a muscarinic antagonist.

Regional clozapine, ECT, and lithium treatment frequency related to lower adolescent excess suicide mortality for 15- to 19-year-olds.

In general population studies, no change observed in general mental health or anxiety symptoms; minimal worsening seen in depression symptoms

The table provided is a review of notable updates that occurred in February 2023 for investigational products in development.

Improvement in well-being and remission seen with aripiprazole-augmentation of existing antidepressants

Patients will be required to see a doctor in person to get a first prescription for opioids, ADHD drugs

No signs of higher risk seen for developmental disorders

No such association seen for Black older adults followed for 15 years, regardless of sleep duration

Almost 60 percent of girls, almost 70 percent of LBGQ+ students experienced feelings of persistent sadness or hopelessness in past year

Black patients and Hispanic patients 40 percent less likely to have mental health concern addressed than Whites and non-Hispanics, respectively

A central objective of addressing moral distress is to permit clinicians to effectively perform their professional functions and thus better help patients.

Authors say automated approach could be used to improve early autism screening

A PDUFA target date of August 5, 2023 has been set for the application.

Loneliness still increases risk even if individual is not socially isolated

Among U.S. Veterans, risk was lower for supplemented Black veterans and those with 0 to 19 ng/mL vitamin D serum levels

In 11 comparisons, antidepressants were efficacious, but they were inefficacious or evidence was inconclusive for 31 comparisons

Seena Fazel of the University of Oxford, UK, and colleagues at the Karolinska Institute in Sweden compared the medicated and non-medicated periods of over 1.4 million beta blocker users.

8.4 percent of adults took sleep meds every day or most days in last 30 days; women were more likely to take sleep meds than men

The updated recommendations include both nonpharmacologic and pharmacologic interventions for adults in the acute phase of MDD.

U.S. health officials are cracking down on the inappropriate use of antipsychotic drugs to sedate patients in nursing homes