Poisoning & Drug Dependence

Highest odds of opioid overdose seen when both the individual and another household member had opioid fills in previous 6 months.

The product was designed using the Amphastar’s proprietary nasal delivery device.

The table provided is a review of notable updates that occurred in February 2023 for investigational products in development.

Opioids accounted for 24.1 percent of substances contributing to deaths in 2005 and 52.2 percent in 2018

In 2011, following reports of serious livery injury, the FDA had required manufacturers of prescription acetaminophen combination products to limit the amount of acetaminophen to 325mg per tablet or capsule.

While not approved for human use, xylazine has been detected in combination with opioids (eg, illicit fentanyl), and with stimulants (eg, methamphetamine, cocaine).

Agency has faced criticism from antitobacco advocates, the industry, and lawmakers for its past work in cigarette and vaping regulation

Proportion of deaths co-involving methamphetamine and heroin or fentanyl peaked at 61.2 percent in 2021

Adverse outcomes included small for gestational age, medically indicated preterm birth, stillbirth, or hypertensive disorders of pregnancy

Narcan Nasal Spray is an opioid antagonist that reverses the effects of opioids, including respiratory depression, sedation, and hypotension.

Authors say this may reflect peer influence on substance use, as decreases were not seen for older adults

Authors say providers should routinely ask older adults about cannabis use

Under the FDA’s orders, the Company may not market or distribute these products in the US.

Proportion of overdose deaths did not increase in association with actions taken to ease access to buprenorphine

OPNT003 is an intranasal formulation containing the high affinity opioid antagonist, nalmefene.

Canadian provinces permitting edible cannabis sales experienced much larger increases in hospitalizations for unintentional poisoning

Maternal, neonatal outcomes similar to buprenorphine monotherapy

Those with current alcohol use disorder or abstinent with alcohol use disorder history had lower likelihood of receiving direct-acting antivirals

RiVive is an opioid antagonist that reverses the effects of opioids, including respiratory depression, sedation, and hypotension.

However, early electronic cigarette quitters plus stable cigarette use was the most common trajectory in 41.6 percent of participants