Over 9 months, the treatment arm prescribed 11.1% fewer quetiapine days per prescriber vs the control arm (P<.001; adjusted difference, −319 days; P<.001), which persisted over 2 years (15.6% fewer days; P<.001).
Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.
Only 20% of the patients who died by suicide had a palliative care encounter, compared with 57% among lung cancer patients whose cause of death was not suicide.
The percentage of patients seen at children's hospital for suicidal ideation (SI) and suicide attempts (SA) more than doubled between 2008 and 2015.
The researchers found that the odds of SA during or after second deployment were increased among soldiers whose first deployment occurred within the first 12 months of service versus after 12 months and among those with a DT of 6 months or less versus longer than 6 months.
Compared with both healthy controls and infants exposed to untreated maternal depression, significant gray matter volume expansion was seen in the right amygdala and right insula in SSRI-exposed infants in voxel-based morphometry.
A meta-analysis reviewing the effect of parent-child book reading interventions revealed a positive correlation between such interventions and a broad range of beneficial psychosocial outcomes, including social-emotional competence, quality of life, and parenting competence.
The Breakthrough Therapy designation is intended to offer a potentially expedited development path and review for promising drug candidates.
The 24-week assessment showed the largest difference between treatments. The WET group had significantly fewer dropouts than the CPT group (4 versus 25).
The researchers found that greater depressive symptoms were associated with significantly shorter survival (hazard ratio, 0.868; P<0.001), higher rates of chemoradiation interruption (odds ratio, 0.865; P=0.010).
Results showed that cariprazine significantly delayed the time to relapse compared to placebo (P=0.0010). A total of 49.5% (n=49/99) of placebo treated patients relapsed vs. 29.7% (n=30/101) for the cariprazine treated patients.
"The Treatment Initiation and Participation Program is an effective intervention to improve early adherence to pharmacotherapy," the authors write. "Improved adherence can promote improvement in depression."
In both studies, more participants on LDX versus placebo were categorized as improved on the Clinical Global Impressions-Improvement starting at week one.
The researchers found an association between greater AD pathology and worse subjective sleep quality, more sleep problems, and daytime somnolence.
Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.
Nelotanserin is a novel once-daily oral 5HT2A inverse agonist. The 5HT2A receptor has been associated with neuropsychiatric effects, including visual hallucinations.
The researchers found that during venlafaxine treatment there was an increase in CTX and a decrease in P1NP, which was consistent with accelerated bone loss.
The study found the gender gap appears 2 to 3 years earlier than previously thought, from 13 to 15 down to age 12.
The gradual trend toward recommending lower dosages of chlorpromazine has arisen not due to trial based evidence, but rather clinical experience and consensus.
The researchers hypothesized that some antimuscarinics with "high lipophilicity, neutral polarity, or low molecular size still cross the blood-brain barrier and further affect neurotransmission in the brain," which could possibly trigger the depressive symptoms.
Adolescents who met criteria for anorexia nervosa or bulimia nervosa were 2.4 and 1.9 times, respectively, more likely to seek treatment than adolescents who met criteria for binge-eating disorder.
Hauser, Robert A. et al. "KINECT 3: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Valbenazine for Tardive Dyskinesia"
The patient presented with complaints of increased muscle tone in her back muscles and the right side of her body starting in adolescence.
Female athletes appear to be more likely than males to suffer concussions during their careers on the field, according to a new study by researchers at Columbia University, New York.
Pediatricians should be comfortable with treating and screening for sexual assault, and they should know where to send their teenage patients for any additional help, according to a clinical report from the American Academy of Pediatrics (AAP) published online in Pediatrics.
The American Academy of Pediatrics (AAP) has published guidance to challenge any perception that marijuana is safe, even as 29 states allow its use.