Psychiatric Disorders

FDA Issues Statement Addressing Safety Concerns Associated With Nuplazid

By September 21, 2018

Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.

Many Foster Kids Inappropriately Prescribed Psychiatric Drugs

September 18, 2018

A report from the Department of Health and Human Services (HHS) found that 1 in 3 foster children sampled in 5 states received the drugs without treatment plans or follow-up.

Many Older Adults Transition to Long-Term Benzodiazepine Use

September 14, 2018

The researchers found that 26.4% of adults met the definition of long-term use 1 year after the index prescription; they were prescribed a mean of 232.7 benzodiazepine days.

Physician Burnout Rates Vary by Medical Specialty

September 11, 2018

Nearly half of those in critical care, neurology, family medicine, ob-gyn, internal medicine report burnout

Treating Older Adult Bipolar Disorder: Newer Atypical Antipsychotics Compared

By September 10, 2018

While pharmacologic agents such as lithium and valproic acid have been shown to provide significant antimanic effects in older adults with bipolar disorder, an increase in the use of atypical antipsychotics in the general adult bipolar population prompted researchers to investigate the efficacy and tolerability of these agents in OABD.

Guidelines for Managing Perimenopausal Depression Now Available

By September 05, 2018

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products).

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

By September 04, 2018

The NDA includes five Phase 3 studies in patients with treatment-resistant depression: 3 short-term studies, 1 withdrawal maintenance of effect study, and 1 long-term safety study.

Self-Injury Tops Diabetes As Cause of Death in United States

September 04, 2018

The researchers found that in 2015, SIM surpassed diabetes as a cause of death in the United States. In 2016, the gap expanded, with rates of 29.1 and 24.8 per 100,000 population, respectively.

Risk of Depression Up in Autism Spectrum Disorder

September 04, 2018

The researchers found that by age 27 years, 19.8% of individuals diagnosed with ASD had a diagnosis of depression, compared with 6.0% among the general population (adjusted relative risk [RR], 3.64).

FDA Rejects ADHD Drug NDA Citing Need for More Data

By August 31, 2018

The FDA stated that the dasotraline NDA cannot be approved in its current form and is requiring additional data to further assess the efficacy and tolerability of the drug.

Psychosis Treatments

August 30, 2018

A comparative dosing and titration chart of commonly used first-generation and second-generation antipsychotics.

Psychotropic Drug Indications

August 30, 2018

A comparative list of psychotropic medications with their mood disorder indications (bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others).

Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder

By August 27, 2018

With regard to safety, treatment with lithium in this patient population was considered "generally safe, at least in the short term."

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

By August 22, 2018

The trial will be a Phase 2b dose-ranging study (N=216) with patients from 12-15 research centers across Europe and North America.

Midlife Deaths Increase in the United States

August 20, 2018

The researchers found that all-cause mortality increased among non-Hispanic (NH) whites, NH American Indians, and Alaskan Natives.

TMS Device Cleared to Treat Obsessive Compulsive Disorder

By August 17, 2018

Transcranial magnetic stimulation (TMS) uses magnetic fields to stimulate nerve cells in the brain.

Traumatic brain injury associated with higher rate of suicide

August 16, 2018

In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.

Case: Hypertensive Crisis Following Use of Armodafinil + MAOI

By August 15, 2018

This case involved a 36-year-old female with bipolar disorder who presented to the emergency department (ED) with blurry vision, neck stiffness and the "worst headache of (her) life" after taking armodafinil with tranylcypromine.

Does Prenatal Tdap Vaccination Increase Autism Risk in Offspring?

By August 14, 2018

Currently, the Advisory Committee on Immunization Practices (ACIP) recommends pregnant women receive the Tdap vaccination to prevent pertussis infection.

Sedation Level Does Not Impact Delirium Risk After Hip Fx Repair

August 13, 2018

The researchers found that the overall incident delirium risk was 36.5%; 39 vs 34%, respectively, in the heavier and lighter sedation groups (P=.46).

ADHD Medications Compared for Efficacy, Tolerability in Children and Adults

By August 13, 2018

The 7 treatments included in the study were amphetamines (including lisdexamfetamine), atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil.

Jornay PM Approved for the Treatment of ADHD

By August 09, 2018

Jornay PM utilizes the proprietary Delexis drug delivery platform which consists of 2 functional film coatings: the first layer delays the initial drug release for up to 10 hours and the second layer helps control the release rate of the active ingredient throughout the day.

Most Antipsychotics Prescribed in Nursing Homes Initiated There

August 09, 2018

The researchers found that 64% of study participants had new antipsychotic use initiated in nursing homes, 18.6% had initiation in hospitals, and 17.5% had initiation in outpatient settings.

Antidepressants and Bleeding Risk: What's the Link?

By August 08, 2018

Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.

CDC: Use of Unapproved Opioid-Like Antidepressant on the Rise in the US

By August 07, 2018

While approved in Europe, Asia, and Latin America, tianeptine, an opioid receptor agonist, is an unscheduled pharmaceutical agent in the US that has been linked to serious adverse events, including death, when used for recreational purposes.

Medical Boards May Contribute to Mental Health Stigma for Doctors

July 31, 2018

Many state medical boards persist in questioning licensure applicants about their history of treatment for mental health instead of focusing on their current fitness to practice.

Once-Monthly Perseris Approved for the Treatment of Schizophrenia

By July 30, 2018

Perseris, an atypical antipsychotic, has an extended-release delivery system that releases sustained levels of risperidone over 1 month.

Phase 3 Trial of Potential PTSD Treatment Halted

By July 27, 2018

Participants in the trial were randomized to receive Tonmya 5.6mg sublingually at bedtime for 12 weeks or placebo sublingual tablets.

Off-Label Prescribing Common With Certain Psychiatric Medications

By July 26, 2018

Using data from the 2012 and 2013 National Ambulatory Medical Care Surveys, researchers looked at all adult outpatient visits to psychiatric practices for chronic care management in which ≥1 psychiatric medication was prescribed.

Dasotraline Effective in Phase 3 Binge Eating Disorder Trial

By July 25, 2018

The results from this trial follow similar positive findings from a flexible-dose study of dasotraline.